Biocatalytic reduction of prochiral aromatic ketones to optically pure alcohols by a coupled enzyme system for cofactor regeneration

被引：15
|
作者：
Yan, Zhen [1 ,2 ]
Nie, Yao [1 ,2 ]
Xu, Yan [1 ,2 ]
Liu, Xiang [3 ]
Xiao, Rong [4 ]
机构：
[1] Jiangnan Univ, Sch Biotechnol, Wuxi 214122, Peoples R China
[2] Jiangnan Univ, Minist Educ, Key Lab Ind Biotechnol, Wuxi 214122, Peoples R China
[3] Jiangnan Univ, Sch Chem & Mat Engn, Wuxi 21412, Peoples R China
[4] Rutgers State Univ, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA
来源：
TETRAHEDRON LETTERS | 2011年 / 52卷 / 09期
基金：
中国国家自然科学基金; 国家高技术研究发展计划(863计划);
关键词：
Asymmetric carbonyl reduction; Cofactor regeneration; Enzyme-coupled system; Cell-free extract; CELL-FREE-EXTRACT; ASYMMETRIC REDUCTION; CARBONYL REDUCTASE; HIGHLY EFFICIENT; CHEMOENZYMATIC SYNTHESIS; CANDIDA-PARAPSILOSIS; ESCHERICHIA-COLI; CARBOXYLIC-ACIDS; CHIRAL ALCOHOLS; POWERFUL TOOL;
D O I：
10.1016/j.tetlet.2010.12.069
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple, highly efficient, and economical biphasic cell-free system was developed for biocatalytic reduction of prochiral aromatic ketones to furnish enantiopure alcohols. This system is characterized by using endogenous enzymes of the cell-free extract to form enzyme-coupled NADPH recycling system. Besides, it offered much higher productivity than whole cells and greatly simplified the preparation process of biocatalysts in comparison with isolated enzymes. Various prochiral aromatic ketones, especially a-substituted acetophenone derivatives, were reduced to chiral alcohols with excellent enantiomeric excess (ee) and moderate to good yield by this cell-free system. (C) 2010 Published by Elsevier Ltd.
引用
收藏
页码：999 / 1002
页数：4
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