A green approach for the sustained-intestinal delivery of red chili (Capsicum annum L) extracted capsaicinoids with enhanced bioavailability

被引：5

作者：

Joseph, Ashil ^{[1
]}

Balakrishnan, Abhilash Maliakkal ^{[1
]}

Mulakal, Johannah Natinga ^{[1
]}

Das Sivadasan, Syam ^{[1
]}

Mohan, Ratheesh ^{[2
]}

Maliakel, Balu ^{[1
]}

Madhavamenon, Krishnakumar Illathu ^{[1
]}

机构：

[1] Akay Nat Ingredients, R&D Ctr, Malaidamthuruth PO, Cochin 683561, Kerala, India

[2] St Thomas Coll, Dept Biochem, Pala, Kerala, India

来源：

JOURNAL OF FUNCTIONAL FOODS | 2021年 / 85卷

关键词：

Beadlets; Capsicum annum L; Capsaicin; Capsifen; Fenugreek dietary fiber; Hydrogel; FENUGREEK DIETARY FIBER; GALACTOMANNANS; FORMULATION; DRUG; RELEASE; INSULIN; PEPPERS; GLUCOSE; TYPE-1; HOT;

D O I：

10.1016/j.jff.2021.104658

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Intestinal delivery with enhanced bioavailability is of great significance for stomach irritating and pungent bioactive molecules. The present study reports the development of a pungency-masked food-grade microbeadlets for the sustained-intestinal delivery of red chili extracted capsaicinoids using fenugreek galactomannans. Capsaicinoids encapsulated microbeads (CapF) of about 250 to 400 mu m were prepared by a gel-phase homogenization, fluid-bed granulation followed by galactomannan coating, and characterized by NMR, FTIR, DSC, PXRD, and SEM as stable, directly compressible, free flowing amorphous beadlets with a tap density of 0.64 +/- 0.2 g/mL. Swelling studies, in vitro release kinetics and particle size analysis indicated the intestinal delivery of soluble capsaicinoids. Pharmacokinetic studies on Wistar rats revealed enhanced bioavailability (19-fold) of CapF when the area under plasma concentration verses time was compared with that of unformulated capsaicinoids. CapF was safe upon gastric mucosa irritation test and demonstrated significant (P < 0.05) anti-obesity effect in high fat diet-induced hypercholesteremic rats.

引用

页数：12

共 2 条

[1] A natural sustained-intestinal release formulation of red chili pepper extracted capsaicinoids (Capsifen®) safely modulates energy balance and endurance performance: a randomized, double-blind, placebo-controlled study
Roopashree, N.
Syam, Das S.
Krishnakumar, I. M.
Mala, K. N.
Fleenor, Bradley S.
Thomas, Jestin
FRONTIERS IN NUTRITION, 2024, 11
[2] A natural sustained-intestinal release formulation of red chili pepper extracted capsaicinoids (Capsifen®) safely modulates energy balance and endurance performance: a randomized, double-blind, placebo-controlled study (vol 11, 1348328, 2024)
Roopashree, N.
Syam, Das S.
Krishnakumar, I. M.
Mala, K. N.
Fleenor, Bradley S.
Thomas, Jestin
FRONTIERS IN NUTRITION, 2024, 11

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