Neonatal Vitamin D Status and Risk of Schizophrenia A Population-Based Case-Control Study

被引:271
|
作者
McGrath, John J. [2 ,3 ,4 ]
Eyles, Darryl W. [2 ,3 ]
Pedersen, Carsten B. [1 ]
Anderson, Cameron [3 ]
Ko, Pauline [2 ,3 ]
Burne, Thomas H. [2 ,3 ]
Norgaard-Pedersen, Bent [5 ]
Hougaard, David M. [5 ]
Mortensen, Preben B. [1 ]
机构
[1] Univ Aarhus, Natl Ctr Register Based Res, DK-8000 Aarhus C, Denmark
[2] Queensland Ctr Mental Hlth Res, Pk Ctr Mental Hlth, Wacol, Australia
[3] Univ Queensland, Queensland Brain Inst, St Lucia, Qld, Australia
[4] Univ Queensland, Dept Psychiat, St Lucia, Qld, Australia
[5] Statens Serum Inst, Sect Neonatal Screening & Hormones, DK-2300 Copenhagen, Denmark
基金
英国医学研究理事会;
关键词
D DEFICIENCY; ADULT-RAT; BIRTH; PREVENTION; ALTERS; 25-HYDROXYVITAMIN-D; HYPERLOCOMOTION; METAANALYSIS; IMMIGRANTS; MORTALITY;
D O I
10.1001/archgenpsychiatry.2010.110
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Context: Clues from the epidemiology of Schizophrenia suggest that low levels of developmental vitamin D may be associated with increased risk of schizophrenia. Objective: To directly examine the association between neonatal vitamin D status and risk of schizophrenia. Design: Individually matched case-control study drawn from a population-based cohort. Setting: Danish national health registers and neonatal biobank. Participants: A total of 424 individuals with schizophrenia and 424 controls matched for sex and date of birth. Main Outcome Measures: The concentration of 25 hydroxyvitamin D-3 (25 [OH] D3) was assessed from neonatal dried blood samples using a highly sensitive liquid chromatography tandem mass spectroscopy method. Relative risks were calculated for the matched pairs when examined for quintiles of 25(OH)D3. Results: Compared with neonates in the fourth quintile (with 25[OH]D3 concentrations between 40.5 and 50.9 nmol/L), those in each of the lower 3 quintiles had a significantly increased risk of schizophrenia (2-fold elevated risk). Unexpectedly, those in the highest quintile also had a significantly increased risk of schizophrenia. Based on this analysis, the population-attributable fraction associated with neonatal vitamin D status was 44%. The relationship was not explained by a wide range of potential confounding or interacting variables. Conclusions: Both low and high concentrations of neonatal vitamin D are associated with increased risk of schizophrenia, and it is feasible that this exposure could contribute to a sizeable proportion of cases in Denmark. In light of the substantial public health implications of this finding, there is an urgent need to further explore the effect of vitamin D status on brain development and later mental health.
引用
收藏
页码:889 / 894
页数:6
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