Dietary administration of tetrodotoxin and its putative biosynthetic intermediates to the captive-reared non-toxic Japanese fire-bellied newt, Cynops pyrrhogaster

被引：18

作者：

Kudo, Yuta ^{[1
]}

Chiba, Chikafumi ^{[2
]}

Konoki, Keiichi ^{[1
]}

Cho, Yuko ^{[1
]}

Yotsu-Yamashita, Mari ^{[1
]}

机构：

[1] Tohoku Univ, Grad Sch Agr Sci, Aoba Ku, 468-1 Aramaki Aza Aoba, Sendai, Miyagi 9800845, Japan

[2] Univ Tsukuba, Fac Life & Environm Sci, Tennoudai 1-1-1, Tsukuba, Ibaraki 3058572, Japan

来源：

TOXICON | 2017年 / 137卷

基金：

日本学术振兴会;

关键词：

Cynops pyrrhogaster; LC-MS; Newt; Tetrodotoxin; Toxin administration; ROUGH-SKIN NEWT; PUFFER FISH; TARICHA-GRANULOSA; TAKIFUGU-PARDALIS; FUGU-POECILONOTUS; BINDING-PROTEIN; ANALOGS; NIPHOBLES; EGGS; ACCUMULATION;

D O I：

10.1016/j.toxicon.2017.07.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The origin of tetrodotoxin (TTX) in amphibians has long been disputed. In this study, TTX and its putative biosynthetic intermediates or shunt compounds (4,9-anhydro-10-hemiketal-5-deoxyTTX and Cep-242) were dietary administered to the captive-reared, non-toxic Japanese fire-bellied newt, Cynops pyrrhogaster. After 4 weeks, the ingested compounds were detected mainly in the newt body using liquid chromatography-mass spectrometry (LC-MS), while these compounds were not converted into other TTX analogues in newts. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：78 / 82

页数：5

共 2 条

[1] Confirmation of the absence of tetrodotoxin and its analogues in the juveniles of the Japanese fire-bellied newt, Cynops pyrrhogaster, captive-reared from eggs in the laboratory using HILIC-LC-MS
Kudo, Yuta
Chiba, Chikafumi
Konoki, Keiichi
Cho, Yuko
Yotsu-Yamashita, Mad
[J]. TOXICON, 2015, 101 : 101 - 105
[2] An Observation of Coiling-around Behavior as a Putative Antipredator Response of the Japanese Fire-Bellied Newt, Cynops pyrrhogaster
Yoshikawa, Natsuhiko
[J]. CURRENT HERPETOLOGY, 2016, 35 (01) : 69 - 72

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