Asymmetric Direct Vinylogous Aldol Reaction of Unactivated γ-Butenolide to Aldehydes

被引：55

作者：

Yang, Yang ^{[1
]}

Zheng, Ke ^{[1
]}

Zhao, Jiannan ^{[1
]}

Shi, Jian ^{[1
]}

Lin, Lili ^{[1
]}

Liu, Xiaohua ^{[1
]}

Feng, Xiaoming ^{[1
]}

机构：

[1] Sichuan Univ, Coll Chem, Minist Educ, Key Lab Green Chem & Technol, Chengdu 610064, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 75卷 / 15期

基金：

中国国家自然科学基金;

关键词：

NAFUREDIN-GAMMA; BRONSTED ACID; MANNICH-TYPE; 2-(TRIMETHYLSILYLOXY)FURAN; 2-TRIMETHYLSILYLOXYFURAN; ORGANOCATALYSIS; LAMBERTELLOLS; DERIVATIVES; ACTIVATION; CATALYSIS;

D O I：

10.1021/jo100946d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric direct vinylogous aldol reaction of unactivated gamma-butenolide with aldehydes has been developed, giving the corresponding 5-(1'-hydroxy)butenolide derivatives in high yields (up to 93%) and enantioselectivities (up to 83% ee) under mild conditions.

引用

页码：5382 / 5384

页数：3

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