Hepatic steatosis in chronic hepatitis C patients infected with genotype 2 is associated with insulin resistance, hepatic fibrosis and affects cumulative positivity of serum hepatitis C virus RNA in peginterferon and ribavirin combination therapy

被引：7
|
作者：
Itoh, Yoshito [1 ]
Nishimura, Takeshi [1 ]
Yamaguchi, Kanji [1 ]
Yokomizo, Chihiro [1 ]
Fujii, Hideki [1 ]
Minami, Masahito [1 ]
Nagao, Yasuyuki [2 ]
Sumida, Yoshio [4 ]
Hashimoto, Hiroaki [3 ]
Umemura, Atsushi [3 ]
Shima, Toshihide [3 ]
Okanoue, Takeshi [3 ]
Yoshikawa, Toshikazu [1 ]
机构：
[1] Kyoto Prefectural Univ Med, Grad Sch Med Sci, Kamigyou Ku, Kyoto 6028566, Japan
[2] Matsushita Mem Hosp, Dept Gastroenterol, Osaka, Japan
[3] Saiseikai Suita Hosp, Hepatol Ctr, Osaka, Japan
[4] Nara City Hosp, Dept Gastroenterol & Hepatol, Nara, Japan
来源：
HEPATOLOGY RESEARCH | 2011年 / 41卷 / 12期
关键词：
chronic hepatitis C; genotype; 2; hepatic fibrosis; hepatic steatosis; homeostasis model assessment-insulin resistance; PEGYLATED INTERFERON-ALPHA; PLUS RIBAVIRIN; NONDIABETIC PATIENTS; HCV GENOTYPE-2; EFFICACY; MONOTHERAPY; RELAPSE; IMPACT; IL28B; TRIAL;
D O I：
10.1111/j.1872-034X.2011.00886.x
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Aim: Hepatic steatosis is one of the factors limiting the virological response to interferon-based antiviral therapy for chronic hepatitis C (CH-C) patients infected with genotype 1, while contradictory results have been reported for genotype 2. We aimed to clarify the effect of hepatic steatosis on therapeutic outcome and cumulative positivity of serum HCV RNA in CH-C patients infected with genotype 2 treated by peginterferon (PEG-IFN)a2b and ribavirin (RBV) combination therapy.
引用
收藏
页码：1145 / 1152
页数：8
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