Lewis acid-Lewis base catalyzed enantioselective hetero-Diels-Alder reaction for direct access to δ-lactones

被引：50
|
作者：
Tiseni, Paolo S. [1 ]
Peters, Rene [1 ]
机构：
[1] ETH, Organ Chem Lab, CH-8093 Zurich, Switzerland
来源：
ORGANIC LETTERS | 2008年 / 10卷 / 10期
关键词：
D O I：
10.1021/ol800742d
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A complex formed in situ from Er(OTf)(3) and a simple commercially available norephedrine ligand promotes an unprecedented [4 + 2] cycloaddition of alpha,beta-unsaturated acid chlorides with a broad range of aromatic and heteroaromatic aldehydes by a cooperative bifunctional Lewis acid-Lewis base catalytic mode of action providing valuable delta-lactone building blocks with excellent enantioselectivity.
引用
收藏
页码：2019 / 2022
页数：4
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