A phase I/II study of SDZ PSC 833 (PSC) in combination with daunorubicin (D) and cytarabine in refractory acute myelogenous leukemia (AML).

被引:0
|
作者
Liliemark, J
Bjorkholm, M
Uden, AM
Hast, R
Paul, C
Simonsson, B
Tidefelt, U
Juliusson, G
Hedenus, M
Evensen, S
Tangen, JM
Sjo, M
Nesthus, I
Hestdal, K
机构
[1] KAROLINSKA HOSP,DEPT ONCOL,S-10401 STOCKHOLM,SWEDEN
[2] KAROLINSKA HOSP,DEPT HEMATOL,S-10401 STOCKHOLM,SWEDEN
[3] SODER SJUKHUSET,DEPT HEMATOL,STOCKHOLM,SWEDEN
[4] DANDERYD HOSP,DEPT HEMATOL,STOCKHOLM,SWEDEN
[5] HUDDINGE HOSP,DEPT HEMATOL,STOCKHOLM,SWEDEN
[6] UNIV UPPSALA HOSP,DEPT HEMATOL,UPPSALA,SWEDEN
[7] REG HOSP,DEPT HEMATOL,OREBRO,SWEDEN
[8] LINKOPING UNIV HOSP,DEPT HEMATOL,S-58185 LINKOPING,SWEDEN
[9] SUNDSVALL HOSP,DEPT HEMATOL,SUNDSVALL,SWEDEN
[10] ULLEVAL HOSP,RIKSHOSP,DEPT HEMATOL,OSLO,NORWAY
[11] REG HOSP,DEPT HEMATOL,TROMSO,NORWAY
[12] HAUKELAND HOSP,DEPT HEMATOL,N-5021 BERGEN,NORWAY
[13] SANDOZ,DEPT HEMATOL,OSLO,NORWAY
关键词
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
引用
收藏
页码:854 / 854
页数:1
相关论文
共 50 条
  • [1] Phase I study of mitoxantrone plus etoposide with multidrug blockade by SDZ PSC-833 in relapsed or refractory acute myelogenous leukemia
    Kornblau, SM
    Estey, E
    Madden, T
    Tron, HT
    Zhao, S
    Consoli, U
    Snell, V
    SanchezWilliams, G
    Kantarjian, H
    Keating, M
    Newman, RA
    Andreeff, M
    JOURNAL OF CLINICAL ONCOLOGY, 1997, 15 (05) : 1796 - 1802
  • [2] A phase I/II study of the MDR modulator Valspodar (PSC 833) combined with daunorubicin and cytarabine in patients with relapsed and primary refractory acute myeloid leukemia
    Gruber, A
    Björkholm, M
    Brinch, L
    Evensen, S
    Gustavsson, B
    Hedenus, M
    Juliusson, G
    Löfvenberg, E
    Nesthus, I
    Simonsson, B
    Sjo, M
    Stenke, L
    Tangen, JM
    Tidefelt, U
    Udén, AM
    Paul, C
    Liliemark, J
    LEUKEMIA RESEARCH, 2003, 27 (04) : 323 - 328
  • [3] A phase I study of mitoxantrone plus VP-16 with multidrug (MDR) blockade by SDZ PSC-833 in relapsed or refractory acute myelogenous leukemia (R-AML)
    Kornblau, SM
    Estey, E
    Consoli, U
    Zhao, S
    Snell, V
    Newman, R
    Andreeff, M
    BLOOD, 1995, 86 (10) : 2044 - 2044
  • [4] Daunorubicin and cytarabine compared with daunorubicin, cytarabine and the MDR1 reversal agent PSC-833 in elderly patients with acute myelogenous leukemia.
    van der Holt, B
    Sonneveld, P
    Burnett, AK
    Vossebeld, PJM
    Beverloo, B
    Rosenkranz, G
    Dugan, M
    van Putten, WLJ
    Wheatley, K
    Lowenberg, B
    BLOOD, 2004, 104 (11) : 246A - 246A
  • [5] Modulation of anthracycline resistance in poor-risk acute myeloid leukemia (AML) with SDZ PSC-833: Results of a phase I/II multicenter study.
    List, AF
    Karanes, C
    Dorr, R
    Spier, C
    Grogan, T
    Greer, J
    Moore, J
    Weinberger, J
    Schiller, G
    Dalton, W
    Pearce, T
    Litchman, M
    BLOOD, 1996, 88 (10) : 1156 - 1156
  • [6] A phase I dose-finding study of PSC 833, a novel MDR reversing agent, with mitoxantrone, etoposide and cytarabine (PSC-MEC) in poor prognosis acute leukemia (AML).
    Visani, G
    Milligan, D
    Leoni, F
    Chang, J
    Kelsey, S
    Marcus, R
    Powles, R
    Schey, S
    Covelli, A
    BLOOD, 1997, 90 (10) : 2518 - 2518
  • [7] Treatment of refractory/relapsed AML with PSC833 plus mitoxantrone, etoposide, cytarabine (PSC-MEC)
    Advani, R
    Saba, H
    Rowe, JM
    Tallman, M
    Wiernik, P
    Ramek, J
    Dugan, K
    Litchman, M
    Dorr, R
    Lum, B
    Sikic, B
    Davis, E
    Paietta, E
    Greenberg, P
    BLOOD, 1996, 88 (10) : 847 - 847
  • [8] Phase I study of the chemosensitizer SDZ PSC 833 in combination with VAD chemotherapy to reverse multidrug resistance.
    Dalton, W
    Greipp, P
    Greenberg, P
    Stiff, P
    Ballester, O
    Friedenberg, W
    Salmon, S
    Kyle, R
    Charnick, S
    Pearce, T
    BLOOD, 1996, 88 (10) : 2638 - 2638
  • [9] PHASE-I STUDY OF SDZ PSC833 COMBINED WITH VAD IN PATIENTS WITH REFRACTORY MULTIPLE-MYELOMA
    SONNEVELD, P
    MARIE, JP
    GROENEWEGEN, A
    BLOOD, 1994, 84 (10) : A181 - A181
  • [10] Phase I/II study of the P-glycoprotein modulator PSC 833 in patients with acute myeloid leukemia
    Dorr, R
    Karanes, C
    Spier, C
    Grogan, T
    Greer, J
    Moore, J
    Weinberger, B
    Schiller, G
    Pearce, T
    Litchman, M
    Dalton, W
    Roe, D
    List, AF
    JOURNAL OF CLINICAL ONCOLOGY, 2001, 19 (06) : 1589 - 1599