Colorectal medullary carcinoma: heterogeneous presentations of a rare clinico-pathological entity. Report of two cases

被引:0
|
作者
Romanzi, Andrea [1 ]
Centonze, Giovanni [2 ]
Sabella, Giovanna [2 ]
Cattaneo, Laura [2 ]
Battiston, Carlo [3 ]
Di Lorenzo, Nadia [4 ]
Milanesi, Maria [1 ]
Putorti, Antonella [1 ]
Rossi, Fabrizio [1 ]
Scolaro, Roberta [1 ]
Zanardo, Michel [1 ]
Vignati, Barbara [5 ]
Vannelli, Alberto [1 ]
机构
[1] Valduce Hosp, Dept Gen Surg, Via Dante Alighieri 11, I-22100 Como, Italy
[2] Fdn IRCCS Ist Nazl Tumori Milano, Dept Pathol & Lab Med, Pathol Unit 1, Milan, Italy
[3] Fdn IRCCS Ist Nazl Tumori Milano, Gastrointestinal Surg & Liver Transplantat, Milan, Italy
[4] Valduce Hosp, Dept Pathol & Lab Med, Como, Italy
[5] Univ Milan, Dept Clin & Biomed Sci Luigi Sacco, Milan, Italy
来源
TUMORI JOURNAL | 2022年 / 108卷 / 06期
关键词
Colorectal cancer; medullary carcinoma; surgical oncology; gastrointestinal oncology; case report; COLON; ADENOCARCINOMA; PROFILE;
D O I
10.1177/03008916221082996
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Colorectal medullary carcinoma (CMC) is a rare subset of minimally differentiated carcinomas. CMC tend to be right-sided and present at an advanced stage. Despite this, distant metastases are rare at presentation. The liver and the regional lymph nodes represent the most common sites of metastases. Most of the time, CMCs exhibit mismatch repair deficiency and a strong association with high-level microsatellite instability. There is no conspicuous data regarding treatment strategies and short-term outcomes. CMC is supposed to be related to better prognosis compared to poorly-differentiated and undifferentiated colonic adenocarcinomas, but reports are controversial. This lesion, with heterogeneous presentations and unclear prognostic significance, may be unfamiliar to histopathologists and can lead to diagnostic uncertainty and overtreatments. Our aim is to renew the attention to this rare histological subtype through the report of two cases.
引用
收藏
页码:NP20 / NP25
页数:6
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