Radiographic Outcomes Were Associated with Pain and Function Responses: Post-Hoc Analysis of Results from a Phase 2 Study of a Small Molecule Wnt Pathway Inhibitor, SM04690, for Knee Osteoarthritis Treatment

被引：0

作者：

Yazici, Yusuf ^{[1
]}

McAlindon, Timothy E. ^{[2
]}

Gibofsky, Allan ^{[3
,4
]}

Lane, Nancy E. ^{[5
]}

Skrepnik, Nebojsa ^{[6
]}

Armas, Eddie ^{[7
]}

Swearingen, Christopher J. ^{[1
]}

DiFrancesco, Anita ^{[1
]}

Tambiah, Jeymi ^{[1
]}

Hochberg, Marc ^{[8
,9
]}

机构：

[1] Samumed LLC, San Diego, CA USA

[2] Tufts Med Ctr, Div Rheumatol, Boston, MA USA

[3] Weill Cornell Med, Rheumatol, New York, NY USA

[4] Hosp Special Surg, 535 E 70th St, New York, NY 10021 USA

[5] Univ Calif Davis, Sch Med, Ctr Musculoskeletal Hlth, Sacramento, CA 95817 USA

[6] Tuscon Orthoped Inst, Tucson, AZ USA

[7] Well Pharma Med Res, Miami, FL USA

[8] Univ Maryland, Sch Med, Div Rheumatol & Clin Immunol, Baltimore, MD 21201 USA

[9] Univ Maryland, Sch Med, Dept Med, Baltimore, MD 21201 USA

来源：

ARTHRITIS & RHEUMATOLOGY | 2017年 / 69卷

关键词：

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

1204

引用

页数：2

共 50 条

[1] RADIOGRAPHIC OUTCOMES WERE ASSOCIATED WITH PAIN AND FUNCTION RESPONSES: POST-HOC ANALYSIS FROM A PHASE 2 STUDY OF A WNT PATHWAY INHIBITOR, SM04690, FOR KNEE OSTEOARTHRITIS TREATMENT
Swearingen, C.
Tambiah, J.
Gibofsky, A.
Lane, N.
McAlindon, T.
Hochberg, M.
ANNALS OF THE RHEUMATIC DISEASES, 2018, 77 : 793 - 793
[2] RADIOGRAPHIC OUTCOMES WERE CONCORDANT WITH OUTCOME MEASURES IN RHEUMATOLOGY-OSTEOARTHRITIS RESEARCH SOCIETY INTERNATIONAL (OMERACT-OARSI) STRICT RESPONSE: POST-HOC ANALYSIS FROM A PHASE 2 STUDY OF A WNT PATHWAY INHIBITOR, SM04690, FOR KNEE OSTEOARTHRITIS TREATMENT
Yazici, Y.
McAlindon, T. E.
Gibofsky, A.
Lane, N. E.
Swearingen, C. J.
Tambiah, J. R.
OSTEOARTHRITIS AND CARTILAGE, 2018, 26 : S244 - S245
[3] DISCOVERY OF A SMALL MOLECULE INHIBITOR OF THE WNT PATHWAY (SM04690) AS A POTENTIAL DISEASE MODIFYING TREATMENT FOR KNEE OSTEOARTHRITIS
Hood, J. D.
Deshmukh, V.
Barroga, C.
Hu, Y.
OSTEOARTHRITIS AND CARTILAGE, 2016, 24 : S14 - S15
[4] DISCOVERY OF A SMALL MOLECULE INHIBITOR OF THE WNT PATHWAY (SM04690) AS A POTENTIAL DISEASE MODIFYING TREATMENT FOR KNEE OSTEOARTHRITIS
Hood, J.
Barroga, C.
Hu, Y.
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ANNALS OF THE RHEUMATIC DISEASES, 2016, 75 : 81 - 81
[5] DISCOVERY OF A SMALL MOLECULE WNT PATHWAY INHIBITOR (SM04690) AS A POTENTIAL DISEASE MODIFYING TREATMENT FOR KNEE OSTEOARTHRITIS
Lane, N. E.
Deshmukh, V.
Barroga, C.
Hu, H.
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Yazici, Y.
OSTEOPOROSIS INTERNATIONAL, 2017, 28 : S56 - S57
[6] ANTI-INFLAMMATORY PROPERTIES OF SM04690, A SMALL MOLECULE INHIBITOR OF THE WNT PATHWAY AS A POTENTIAL TREATMENT FOR KNEE OSTEOARTHRITIS
Deshmukh, V.
Barroga, C.
Ibanez, M.
Seo, T.
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[7] A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee
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Hu, H.
Barroga, C.
Bossard, C.
Kc, S.
Dellamary, L.
Stewart, J.
Chiu, K.
Ibanez, M.
Pedraza, M.
Seo, T.
Do, L.
Cho, S.
Cahiwat, J.
Tam, B.
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Hood, J.
Lane, N. E.
Yazici, Y.
OSTEOARTHRITIS AND CARTILAGE, 2018, 26 (01) : 18 - 27
[8] ANTI-INFLAMMATORY PROPERTIES OF SM04690, A SMALL MOLECULE INHIBITOR OF THE WNT PATHWAY AS A POTENTIAL TREATMENT FOR KNEE OSTEOARTHRITIS
Deshmukh, V.
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Ibanez, M.
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ANNALS OF THE RHEUMATIC DISEASES, 2017, 76 : 984 - 984
[9] JOINT SPACE WIDTH INCLUSION CRITERIA CAN REDUCE KNEE OSTEOARTHRITIS TRIAL HETEROGENEITY: POST-HOC DATA FROM A PHASE 2 TRIAL OF WNT PATHWAY INHIBITOR, SM04690
Conaghan, P.
Tambiah, J.
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OSTEOARTHRITIS AND CARTILAGE, 2018, 26 : S274 - S275
[10] OPTIMIZING SUBJECT SELECTION IN KNEE OSTEOARTHRITIS CLINICAL TRIALS BY RADIOGRAPHIC JOINT SPACE WIDTH: POST-HOC CLINICAL RESPONSE ANALYSIS FROM A PHASE 2B TRIAL OF WNT PATHWAY INHIBITOR, SM04690
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ANNALS OF THE RHEUMATIC DISEASES, 2019, 78 : 144 - 144

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