Mutation of the CD28 Costimulatory Domain Confers Decreased CAR T Cell Exhaustion

被引：2
|
作者：
Boucher, Justin C. [1 ]
Li, Gongbo [1 ]
Shrestha, Bishwas [1 ]
Cabral, Maria [2 ]
Morrissey, Dylan [3 ]
Guan, Lawrence [3 ]
Davila, Marco L. [1 ]
机构：
[1] H Lee Moffitt Canc Ctr & Res Inst, Div Clin Sci, Tampa, FL USA
[2] Univ S Florida, Dept Cell Biol Microbiol & Mol Biol, Tampa, FL USA
[3] Univ S Florida, Morsani Coll Med, Tampa, FL USA
来源：
BLOOD | 2018年 / 132卷
关键词：
D O I：
10.1182/blood-2018-99-110645
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
966
引用
收藏
页数：3
相关论文
共 50 条
  • [1] Mutation of the CD28 costimulatory domain confers increased CAR T cell persistence and decreased exhaustion
    Boucher, Justin C.
    Li, Gongbo
    Shrestha, Bishwas
    Zhang, Yongliang
    Vishwasrao, Paresh
    Cabral, Maria L.
    Guan, Lawrence
    Davila, Marco L.
    JOURNAL OF IMMUNOLOGY, 2018, 200 (01):
  • [2] Mutation of the CD28 Co-Stimulatory Domain Confers Enhanced CAR T Cell Function
    Boucher, Justin C.
    Li, Gongbo
    Kotani, Hiroshi
    Cabral, Maria
    Morrissey, Dylan
    Lee, Sae Bom
    Spitler, Kristen
    Beatty, Nolan
    Shrestha, Bishwas
    Yu, Bin
    Kazi, Aslamuzzaman
    Wang, Xuefeng
    Sebti, Said
    Davila, Marco L.
    BLOOD, 2019, 134
  • [3] Novel Phosphorylation Sites in the CD28 Costimulatory Domain Shape CAR-T Cell Function
    Ramello, Maria C.
    Fang, Bin
    Koomen, John M.
    Haura, Eric B.
    Abate-Daga, Daniel
    MOLECULAR THERAPY, 2018, 26 (05) : 52 - 53
  • [4] THE ROLE OF THE EXTRACELLULAR CD28 DOMAIN IN CAR T CELLS: MONOMERISATION AND TRUNCATION IMPACT THE ACTIVATION OF CD28 CAR T CELLS
    Kilgallon, A.
    Hawkins, R.
    Cheadle, E.
    Bridgeman, J.
    Armstrong, A.
    Gilham, D.
    Schutt, A.
    Kalaitsidou, M.
    Kueberuwa, G.
    HUMAN GENE THERAPY, 2019, 30 (12) : A14 - A15
  • [5] CD28 CAR T Cells for the Treatment of T Cell Malignancies
    Willier, Semjon
    Farber, Julian
    Ispyrlidou, Theodora
    Stenger, Dana
    Nikolaides, Sophia L. M.
    Ernst, Paulina Ferrada
    Peters, Annika E.
    Wilhelm, Jonas
    Stoll, Nadine
    Breidenbach, Maike
    Becker-Dettling, Fiona Ag
    Blaeschke, Franziska
    Kaeuferle, Theresa
    Yassin, Abdallah A. H. A.
    Klein, Christoph
    Feuchtinger, Tobias
    BLOOD, 2023, 142
  • [6] CD28 T-cell costimulatory molecule expression in pemphigus vulgaris
    Alecu, M.
    Ursaciuc, C.
    Surcel, M.
    Coman, G.
    Ciotaru, D.
    Dobre, M.
    JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY, 2009, 23 (03) : 288 - 291
  • [7] IFNg Impedes Antigen-Specific Proliferation of CAR-T with a CD28, but Not 4-1BB, Costimulatory Domain
    Bailey, Stefanie R.
    Vatsa, Sonika
    Silva, Harrison
    Larson, Rebecca C.
    Kann, Michael C.
    Grauwet, Korneel
    Leick, Mark B.
    Maus, Marcela V.
    MOLECULAR THERAPY, 2022, 30 (04) : 46 - 46
  • [8] Molecular cloning and sequencing of canine T-cell costimulatory molecule (CD28)
    Khatlani, TS
    Ma, ZY
    Okuda, M
    Onishi, T
    VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2001, 78 (3-4) : 341 - 348
  • [9] Genomic expression programs and the integration of the CD28 costimulatory signal in T cell activation
    Diehn, M
    Alizadeh, AA
    Rando, OJ
    Liu, CL
    Stankunas, K
    Botstein, D
    Crabtree, GR
    Brown, PO
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) : 11796 - 11801
  • [10] CD28 Costimulatory Domain-Targeted Mutations Enhance Chimeric Antigen Receptor T-cell Function
    Boucher, Justin C.
    Li, Gongbo
    Kotani, Hiroshi
    Cabral, Maria L.
    Morrissey, Dylan
    Lee, Sae Bom
    Spitler, Kristen
    Beatty, Nolan J.
    Cervantes, Estelle, V
    Shrestha, Bishwas
    Yu, Bin
    Kazi, Aslamuzzaman
    Wang, Xuefeng
    Sebti, Said M.
    Davila, Marco L.
    CANCER IMMUNOLOGY RESEARCH, 2021, 9 (01) : 62 - 74
12345