Total syntheses of marine polycyclic ethers

A review of the total synthesis of marine polycyclic ethers by several synthetic organic chemists who have extensively studied the development of new strategies and efficient methodologies for the construction of ether rings and their application is presented. The intensive endeavors of these chemists have accumulated many efficient strategies and useful methods for construction of various types of polycycling ether ring systems. In addition to the total landmark syntheses of brevetoxin-B (BTX-B) and BTX-A, recent remarkable progress in synthetic organic chemistry has completed efficient syntheses of marine polyethers, including BTX-B, ciguatoxin CTX3C, gambierol and gymnocin-A.