Is large birth weight associated with asthma risk in early childhood?

被引：10
|
作者：
To, Teresa [1 ,2 ,3 ,4 ]
Guan, Jun [4 ]
Wang, Chengning [1 ]
Radhakrishnan, Dhenuka [1 ]
McLimont, Susan [1 ]
Latycheva, Oxana [5 ]
Gershon, Andrea S. [1 ,3 ,4 ,6 ]
机构：
[1] Hosp Sick Children, Toronto, ON M5G 1X8, Canada
[2] Dalla Lana Sch Publ Hlth, Toronto, ON, Canada
[3] Univ Toronto, Dept Hlth Policy Management & Evaluat, Toronto, ON, Canada
[4] Inst Clin Evaluat Sci, Toronto, ON, Canada
[5] Asthma Soc Canada, Toronto, ON, Canada
[6] Sunnybrook Hlth Sci Ctr, Dept Med, Toronto, ON M4N 3M5, Canada
来源：
ARCHIVES OF DISEASE IN CHILDHOOD | 2012年 / 97卷 / 02期
基金：
加拿大健康研究院;
关键词：
COMPLEX CHRONIC CONDITIONS; POPULATION-BASED COHORT; FETAL-GROWTH; YOUNG-ADULTS; HAY-FEVER; ATOPY; CHILDREN; ONTARIO; MARKERS; SIZE;
D O I：
10.1136/adc.2010.187047
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
Objective To determine the association between large birth weight and the risk of developing asthma in early childhood. Methods All single live births (n = 687 194) born in Ontario between 1 April 1995 and 31 March 2001 were followed until their sixth birthday. Their birth weight was categorised as low (<2.5 kg), normal (2.5-4.5 kg), large (4.6-6.5 kg) or extremely large (>6.5 kg). Poisson regression analysis was used. Results Compared with normal-birth-weight infants, large-birth-weight infants (2.3% of total) had a slightly lower risk of developing asthma by age 6 after adjusting for confounders (adjusted RR 0.90, 95% CI 0.86 to 0.93). There was a trend towards increased risk of asthma among extremely large-birth-weight infants (RR 1.21, 95% CI 0.67 to 2.19). Conclusions Contrary to previous reports, large birth weight was associated with a lower risk for asthma. Instead, a trend towards increased risk of asthma was observed among extremely large-birth-weight infants and interventions to reduce the incidence of extreme large birth weight may help reduce the risk of asthma.
引用
收藏
页码：169 / 171
页数：3
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