C18orf2, a novel, highly conserved intronless gene within intron 5 of the GNAL gene on chromosome 18p11

被引：5
|
作者：
Vuoristo, JT
Berrettini, WH
Ala-Kokko, L
机构：
[1] Bioctr Oulu, Collagen Res Unit, Oulu 90220, Finland
[2] Univ Oulu, Dept Med Biochem, SF-90220 Oulu, Finland
[3] Univ Penn, Dept Psychiat, Philadelphia, PA 19104 USA
来源：
CYTOGENETICS AND CELL GENETICS | 2001年 / 93卷 / 1-2期
关键词：
D O I：
10.1159/000056940
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We have characterized a novel intronless human gene (Cl 8orf2) which is embedded in intron 5 of the G-protein gene (GNAL) on chromosome 18p 11. This gene codes for a 199 amino acid polypeptide with a predicted molecular weight of 22.1 kDa. It is highly homologous to a number of predicted developmental proteins in organisms ranging from yeasts to Drosophila. Cl 8orf2 mRNA was found to be expressed in various tissues. Copyright (C) 2001 S. Karger AG, Basel.
引用
收藏
页码：19 / 22
页数：4
相关论文
共 29 条
  • [1] Analysis of variations in the NAPG gene on chromosome 18p11 in bipolar disorder
    Weller, AE
    Dahl, JP
    Lohoff, FW
    Ferraro, TN
    Berrettini, WH
    PSYCHIATRIC GENETICS, 2006, 16 (01) : 3 - 8
  • [2] Sequence analysis of an intronless gene within GNAL on 18q11 in individuals affected with bipolar disorder
    Trofatter, JA
    Nurnberger, KM
    Berrettini, WH
    Nurnberger, JI
    AMERICAN JOURNAL OF MEDICAL GENETICS, 2001, 105 (07): : 592 - 592
  • [3] A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11
    Parker, A
    Meyer, J
    Lewitzky, S
    Rennich, JS
    Chan, GY
    Thomas, JD
    Orho-Melander, M
    Lehtovirta, M
    Forsblom, C
    Hyrkkö, A
    Carlsson, M
    Lindgren, C
    Groop, LC
    DIABETES, 2001, 50 (03) : 675 - 680
  • [4] Sequence and genomic organization of the human G-protein Golfα gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia
    J T Vuoristo
    W H Berrettini
    J Overhauser
    D J Prockop
    T N Ferraro
    L Ala-Kokko
    Molecular Psychiatry, 2000, 5 : 495 - 501
  • [5] Sequence and genomic organization of the human G-protein Golfα gene (GNAL) on chromosome 18p11, a susceptibility region for bipolar disorder and schizophrenia
    Vuoristo, JT
    Berrettini, WH
    Overhauser, J
    Prockop, DJ
    Ferraro, TN
    Ala-Kokko, L
    MOLECULAR PSYCHIATRY, 2000, 5 (05) : 495 - 501
  • [6] Positional candidate gene screening of a locus on chromosome 18p11 linked to type 2 diabetes with obesity
    Orho-Melander, M
    Svensson, M
    Fredriksson, J
    Forsblom, C
    Carlsson, M
    Groop, L
    DIABETOLOGIA, 2001, 44 : A23 - A23
  • [7] Association of mitochondrial complex I subunit gene NDUFV2 at 18P11 with schizophrenia
    Washizuka, Shinsuke
    Kametani, Mizue
    Tochigi, Mamoru
    Umekage, Tadashi
    Kohda, Kazuhisa
    Sasaki, Tsukasa
    Kato, Tadafumi
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2006, 141B (07) : 780 - 780
  • [8] Association between obese Type 2 diabetes and the melanocortin 2 receptor gene (MC2R) on chromosome 18p11
    Sjögren, M
    Svensson, M
    Fredriksson, J
    Groop, L
    Orho-Melander, M
    DIABETOLOGIA, 2004, 47 : A136 - A136
  • [9] Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder
    Washizuka, S
    Kakiuchi, C
    Mori, K
    Kunugi, H
    Tajima, O
    Akiyama, T
    Nanko, S
    Kato, T
    AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2003, 120B (01) : 72 - 78
  • [10] A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11 (vol 50, pg 675, 2001)
    Parker, A
    Meyer, J
    Lewitzky, S
    Rennich, JS
    Chan, G
    Thomas, JD
    Orho-Melander, M
    Lehtovirta, M
    Forsblom, C
    Hyrkkö, A
    Carlsson, M
    Lindgren, C
    Groop, LC
    DIABETES, 2001, 50 (06) : 1512 - 1512
123