Antiproliferative quillaic acid and gypsogenin saponins from Saponaria officinalis L. roots

被引：35
|
作者：
Lu, Yuping [1 ]
Van, Dang [1 ]
Deibert, Leah [1 ]
Bishop, Greg [1 ]
Balsevich, John [1 ]
机构：
[1] Natl Res Council Canada, Saskatoon, SK S7N 0W9, Canada
来源：
PHYTOCHEMISTRY | 2015年 / 113卷
关键词：
Saponins; Saponaria officinalis L; Caryophyllaceae; Quillaic acid; Gypsogenin; 2D NMR spectroscopy; TRITERPENOID SAPONINS; ALAMAR BLUE; IDENTIFICATION; GALACTOSE;
D O I：
10.1016/j.phytochem.2014.11.021
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Nine quillaic acid and five gypsogenin bisdesmosides were isolated from roots of Saponaria officinalis L. (Caryophyllaceae). Seven of the quillaic acid saponins possessed a 3-O-beta-D-galactopyranosyl-(1 -> 2)-[beta-D-xylopyranosyl-(1 -> 3)]-beta-D-glucuronopyranosyl unit, but differed from each other in oligosaccharide units linked to the C-28 ester. The five gypsogenin saponins isolated from the roots all possessed the 3-O-beta-D-galactopyranosyl-(1 -> 2)-[beta-D-xylopyranosyl-(1 -> 3)]-beta-D-glucuronopyranosyl unit, with their oligosaccharide units linked to the C-28 ester differing. Structures were elucidated by extensive 1D and 2D NMR spectroscopy and mass spectrometry. The saponins were evaluated for growth inhibitory activity in two human cancer cell lines and hemolytic activity in sheep red blood cells. Crown Copyright (C) 2014 Published by Elsevier Ltd. All rights reserved.
引用
收藏
页码：108 / 120
页数：13
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