Adoptive immunotherapy with the use of regulatory T cells and virus-specific T cells derived from cord blood

被引：18
|
作者：
Hanley, Patrick J. [1 ,2 ,3 ,4 ]
Bollard, Catherine M. [1 ,2 ,3 ,4 ]
Brunstein, Claudio G. [5 ]
机构：
[1] Childrens Natl Hlth Syst, Program Cell Enhancement & Technol Immunotherapy, Washington, DC 20010 USA
[2] Childrens Natl Hlth Syst, Ctr Canc & Immunol Res, Washington, DC 20010 USA
[3] Childrens Natl Hlth Syst, Div Blood & Marrow Transplantat, Washington, DC 20010 USA
[4] Childrens Natl Hlth Syst, Sheikh Zayed Inst Pediat Surg Innovat, Washington, DC 20010 USA
[5] Univ Minnesota, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA
来源：
CYTOTHERAPY | 2015年 / 17卷 / 06期
关键词：
antiviral; cell therapy; cord blood; graft-versus-host disease; immunotherapy; regulatory T cells (Treg); transplant; EPSTEIN-BARR-VIRUS; VERSUS-HOST-DISEASE; EX-VIVO EXPANSION; DENDRITIC CELLS; PROPHYLACTIC INFUSION; PERIPHERAL-BLOOD; EXPRESS FOXP3; CYTOMEGALOVIRUS; LYMPHOCYTES; DONOR;
D O I：
10.1016/j.jcyt.2014.12.007
中图分类号：
Q813 [细胞工程];
学科分类号：
摘要：
Cord blood transplantation, an alternative to traditional stem cell transplants (bone marrow or peripheral blood stem cell transplantation), is an attractive option for patients lacking suitable stem cell transplant donors. Cord blood units have also proven to be a valuable donor source for the development of cellular therapeutics. Virus-specific T cells and regulatory T cells are two cord blood derived products that have shown promise in early-phase clinical trials to prevent and/or treat viral infections and graft-versus-host disease, respectively. We describe how current strategies that use cord blood derived regulatory T cells and virus-specific T cells have been developed to improve outcomes for cord blood transplant recipients.
引用
收藏
页码：749 / 755
页数：7
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