Genetic Susceptibility to Type 2 Diabetes and Breast Cancer Risk in Women of European and African Ancestry

被引：10

作者：

Hou, Ningqi ^{[1
]}

Zheng, Yonglan ^{[2
]}

Gamazon, Eric R. ^{[2
]}

Ogundiran, Temidayo O. ^{[3
]}

Adebamowo, Clement ^{[4
]}

Nathanson, Katherine L. ^{[5
]}

Domchek, Susan M. ^{[5
]}

Rebbeck, Timothy R. ^{[6
]}

Simon, Michael S. ^{[7
]}

John, Esther M. ^{[8
,9
]}

Hennis, Anselm ^{[10
,11
]}

Nemesure, Barbara ^{[12
]}

Wu, Suh-Yuh ^{[12
]}

Leske, M. Cristina ^{[12
]}

Ambs, Stefan ^{[13
]}

Niu, Qun ^{[2
]}

Zhang, Jing ^{[2
]}

Pierce, Brandon ^{[1
]}

Cox, Nancy J. ^{[2
]}

Olopade, Olufunmilayo I. ^{[2
]}

Huo, Dezheng ^{[1
]}

机构：

[1] Univ Chicago, Dept Hlth Studies, Chicago, IL 60637 USA

[2] Univ Chicago, Dept Med, Chicago, IL 60637 USA

[3] Univ Ibadan, Dept Surg, Coll Med, Ibadan, Nigeria

[4] Univ Maryland, Dept Epidemiol & Prevent Med, Baltimore, MD 21201 USA

[5] Univ Penn, Dept Med, Philadelphia, PA 19104 USA

[6] Univ Penn, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA

[7] Wayne State Univ, Dept Oncol, Karmanos Canc Inst, Detroit, MI USA

[8] Stanford Univ, Sch Med, Dept Hlth Res & Policy, Stanford, CA 94305 USA

[9] Stanford Canc Inst, Stanford, CA USA

[10] Univ W Indies, Chron Dis Res Ctr, Bridgetown, Barbados

[11] Univ W Indies, Res Inst Trop Med, Bridgetown, Barbados

[12] SUNY Stony Brook, Dept Prevent Med, Stony Brook, NY 11794 USA

[13] NCI, Human Carcinogenesis Lab, Bethesda, MD 20892 USA

来源：

CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2012年 / 21卷 / 03期

关键词：

GENOME-WIDE ASSOCIATION; OBESITY;

D O I：

10.1158/1055-9965.EPI-11-0979

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Epidemiologic studies have reported a positive association between type 2 diabetes (T2D) and breast cancer risk, independent of body weight. Methods: We investigated 40 genetic variants known to be associated with T2D in relation to breast cancer risk among 2,651 breast cancer cases and 2,520 controls of African or European ancestry that were pooled from seven studies. Results: We found that two T2D risk alleles in Caucasian women (rs5945326-G, rs12518099-C) and one in women of African ancestry (rs7578597-T) were positively associated with breast cancer risk at a nominal significance level of 0.05, whereas two T2D risk alleles were inversely associated with breast cancer risk in Caucasian women (rs1111875-C, rs10923931-T). The composite T2D susceptibility score (the number of risk allele) was not significantly associated with breast cancer risk. Conclusion: The association between established T2D genetic susceptibility variants and breast cancer risk in women of African or European ancestry is likely weak, if it does exist. Impact: The pleiotropic effects of known T2D risk alleles cannot explain the association between T2D and breast cancer risk. Cancer Epidemiol Biomarkers Prev; 21(3); 552-6. (C) 2012 AACR.

引用

页码：552 / 556

页数：5

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