Ganciclovir-Resistant Cytomegalovirus (CMV) Retinitis in a Patient with Wild-Type CMV in Her Plasma

被引：6
|
作者：
Moss, Hart B. [2 ]
Chavala, Sai [2 ]
Say, Emil [2 ]
Miller, Melissa B. [1 ]
机构：
[1] Univ N Carolina, Sch Med, Dept Pathol & Lab Med, Chapel Hill, NC 27515 USA
[2] Univ N Carolina, Sch Med, Dept Ophthalmol, Chapel Hill, NC USA
来源：
JOURNAL OF CLINICAL MICROBIOLOGY | 2012年 / 50卷 / 05期
关键词：
POLYMERASE-CHAIN-REACTION; DRUG-RESISTANCE; DNA; MUTATIONS; DIAGNOSIS;
D O I：
10.1128/JCM.00029-12
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A patient with systemic cytomegalovirus (CMV), including chorioretinitis, received localized and systemic ganciclovir, systemic cidofovir analog, and localized foscarnet. Mutations conferring ganciclovir and cidofovir resistance were detected in CMV from the aqueous fluid but not in CMV from plasma. Quantifying CMV from aqueous fluid was valuable for monitoring the clinical response and predicting resistance.
引用
收藏
页码：1796 / 1799
页数：4
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