Harnessing soluble CD40L to enhance anti-tumor efficacy of Her2-LAMP DNA vaccine using UNITETM platform

被引：0
|
作者：
Shen, Wei [1 ]
Xu, Renhuan [2 ]
Kao, Yun-Ting [1 ]
Karkada, Mohan [1 ]
Heiland, Teri [1 ]
机构：
[1] Immun Therapeut, Rockville, MD USA
[2] ARV Tech, Rockville, MD USA
来源：
CANCER RESEARCH | 2022年 / 82卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
3553
引用
收藏
页数：2
相关论文
共 8 条
  • [1] Vaccination using different platforms encoding HER2-LAMP with heterologous boosting enhances adaptive HER2-specific immunity to enable potent anti-tumor responses
    Marek, Robert D.
    Chen, Alan
    Xu, Renhuan
    Wei, Junping
    Wang, Tao
    Yang, Xiao
    Lei, Gangjun
    Heiland, Teri
    Hartman, Zachary C.
    CANCER RESEARCH, 2022, 82 (12)
  • [2] Enhanced anti-tumor efficacy of genetically modified T cells through the up-regulated expression of CD154 (CD40L)
    Seinstra, Beatrijs
    Nikhamin, Yan
    Brentjens, Renier
    HUMAN GENE THERAPY, 2007, 18 (10) : 1064 - 1065
  • [3] Constitutive Expression of CD40L by CAR-Modified Tumor Targeted T Cells Enhances Anti-Tumor Efficacy Both in Vitro and in Vivo
    Curran, Kevin J.
    Seinstra, Beatrijs
    Nikhamin, Yan
    Yeh, Raymond
    Usachenko, Yelena
    Brentjens, Renier J.
    BLOOD, 2012, 120 (21)
  • [4] Preclinical development of a first-in-class vaccine encoding HER2, Brachyury and CD40L for antibody enhanced tumor eradication
    Hinterberger, Maria
    Endt, Kathrin
    Bathke, Barbara
    Habjan, Matthias
    Heiseke, Alexander
    Schweneker, Marc
    Von Rohrscheidt, Julia
    Atay, Cigdem
    Chaplin, Paul
    Kalla, Markus
    Hausmann, Juergen
    Schmittwolf, Carolin
    Lauterbach, Henning
    Volkmann, Ariane
    Hochrein, Hubertus
    Medina-Echeverz, Jose
    SCIENTIFIC REPORTS, 2023, 13 (01)
  • [5] Preclinical development of a first-in-class vaccine encoding HER2, Brachyury and CD40L for antibody enhanced tumor eradication
    Maria Hinterberger
    Kathrin Endt
    Barbara Bathke
    Matthias Habjan
    Alexander Heiseke
    Marc Schweneker
    Julia Von Rohrscheidt
    Cigdem Atay
    Paul Chaplin
    Markus Kalla
    Jürgen Hausmann
    Carolin Schmittwolf
    Henning Lauterbach
    Ariane Volkmann
    Hubertus Hochrein
    José Medina-Echeverz
    Scientific Reports, 13
  • [6] CD40L-adjuvanted DNA vaccine carrying EBV-LMP2 antigen enhances anti-tumor effect in NPC transplantation tumor animal
    Lei, Lei
    Li, Jianhui
    Liu, Meiqing
    Hu, Xiaoming
    Zhou, Ya
    Yang, Shiming
    CENTRAL EUROPEAN JOURNAL OF IMMUNOLOGY, 2018, 43 (02) : 117 - 122
  • [7] A novel synthetic CD40L plasmid adjuvant generates unique anti-HPV DNA vaccine induced responses that impact tumor growth
    Wise, Megan C.
    Duperret, Elizabeth K.
    Villarreal, Daniel O.
    Louis, Lumena
    Yan, Jian
    Morrow, Matthew P.
    Humeau, Laurent M.
    Sardesai, Niranjan Y.
    Weiner, David B.
    CANCER IMMUNOLOGY RESEARCH, 2016, 4 (11)
  • [8] IFN-α and 5-Aza-2′-deoxycytidine enhance the anti-tumor efficacy of a dendritic-cell targeting MIP3α-Gp100-Trp2 DNA vaccine by affecting T-cell and Dendritic Cell recruitment into tumor
    Gordy, James
    Markham, Richard
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2019, 7
1