Upregulation of FGF19 in lung adenocarcinoma and predicts poor prognosis

Fibroblast growth factor 19 (FGF19) belong to the FGF19 subfamily which is widely distributed in human tissues. FGF19 plays a crucial role in regulating various cellular processes. Recently, the researchers found that the aberrant expression of FGF19 in tumor development and progression. However, to our limited knowledge, whether FGF19 functions in lung adenocarcinoma remains unknown. In our research, we evaluated the expression of FGF19 in LAC tissues and corresponding normal tissues by Immunohistochemistry and western blot. Moreover, we also demonstrated the FGF19 expression was positively associated with Ki-67, which is a cell proliferation index. Statistics analysis showed FGF19 expression was related with some clinicopathologic parameters and high expression of FGF19 predicted poor prognosis of LAC patients. These findings suggested that up-regulation of FGF19 might potentially be an effective therapeutic approach for LAC.