Pyridazines 92. Synthesis of dialkyldipyridazinodiazepinones as potential HIV-1 reverse transcriptase inhibitors

被引：2
|
作者：
Heinisch, G
Matuszczak, B
Spielmann, E
Witvrouw, M
Pannecouque, C
De Clercq, E
机构：
[1] Univ Innsbruck, Inst Pharm, Dept Pharmaceut Chem, A-6020 Innsbruck, Austria
[2] Katholieke Univ Leuven, Rega Inst Med Res, B-3000 Louvain, Belgium
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 2001年 / 38卷 / 01期
关键词：
D O I：
10.1002/jhet.5570380117
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Two methods for the preparation of dialkylsubstituted dipyridazino[4,3-b:3',4'-e][1,4]diazepinones and dipyridazino[3,4-b:3',4'-e][1,4]diazepinones are reported. The new compounds were evaluated for their inhibitory effects against the replication of human immunodeficiency virus [HIV-1(III(B)) and HIV-2(ROD)] in MT-4 cells.
引用
收藏
页码：125 / 130
页数：6
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