Effective graft-versus-leukaemia effect after allogeneic stem cell transplantation using reduced-intensity preparative regimens in Fanconi anaemia patients with myelodysplastic syndrome or acute myeloid leukaemia

被引：11
|
作者：
Guardiola, P
Kurre, P
Vlad, A
Cayuela, JM
Espérou, H
Devergie, A
Ribaud, P
Socié, G
Richard, P
Traineau, R
Storb, R
Gluckman, E
机构：
[1] Hop St Louis, Serv Greffe Moelle Trefle 3, Bone Marrow Transplant Unit, F-75475 Paris 10, France
[2] Fred Hutchinson Canc Res Ctr, Div Clin Res, Seattle, WA 98104 USA
[3] Hop St Louis, INSERM, U462, Paris, France
[4] Hop St Louis, Cent Hematol Lab, Paris, France
[5] Hop St Louis, Blood Bank Dept, Paris, France
来源：
BRITISH JOURNAL OF HAEMATOLOGY | 2003年 / 122卷 / 05期
关键词：
Fanconi anaemia; allogeneic stem cell transplantation; graft-versus-leukaemia effect; acute leukaemia; myelodysplasia;
D O I：
10.1046/j.1365-2141.2003.04503.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Allogeneic transplantation is the only curative treatment for Fanconi anaemia (FA) patients who develop myeloid malignancies. Dose-intensive preparative regimens, to decrease disease recurrence, lead to unacceptable transplant-related toxicity in FA. We report the outcome of three FA patients with such malignancies who underwent transplantation with reduced-intensity preparative regimens. This approach was well tolerated, even as second transplantations, and resulted in complete leukaemic remissions. However, the graft-versus-leukaemia effect was associated with fatal graft-versus-host disease. Even after transplantation, myeloid malignancies remain associated with a poor outcome in FA, and this argues in favour of early intervention when suitable donors are available.
引用
收藏
页码：806 / 809
页数：4
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