d(TGGGAG) with 5′-nucleobase-attached large hydrophobic groups as potent inhibitors for HIV-1 envelop proteins mediated cell-cell fusion

被引：14

作者：

Chen, Wei ^{[1
]}

Xu, Liang ^{[1
]}

Cai, Lifeng ^{[1
]}

Zheng, Baohua ^{[1
]}

Wang, Kun ^{[1
]}

He, Junlin ^{[1
]}

Liu, Keliang ^{[1
]}

机构：

[1] Beijing Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2011年 / 21卷 / 19期

基金：

中国国家自然科学基金;

关键词：

Hotoda's sequence; TBDPS; Anti-fusion activity; Nucleoside analogues; BIOLOGICALLY-ACTIVE OLIGODEOXYRIBONUCLEOTIDES; ANTI-HIV-1; ACTIVITY; G-QUADRUPLEXES; FORMING OLIGONUCLEOTIDES; DNA; PROMOTER; TGGGAG; APTAMERS; TARGET; 5-UTR;

D O I：

10.1016/j.bmcl.2011.08.007

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The Hotoda's sequence substituted with TBDPS via 5'-end nucleobase existed as parallel quadruplex structure and exhibited inhibitory activities in an HIV-1 envelop proteins mediated cell-cell fusion assay. This result demonstrated that the 5'-aromatic groups of the Hotoda's sequence are allowed to have a large spatial freedom and remain to be optimized for its role in the binding to HIV-1 envelop proteins. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：5762 / 5764

页数：3

共 16 条

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RETROVIROLOGY, 2016, 13

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