European guideline (EuroGuiDerm) on atopic eczema: part I - systemic therapy

被引：151

作者：

Wollenberg, A. ^{[1
,2
]}

Kinberger, M. ^{[3
,4
,5
]}

Arents, B. ^{[6
]}

Aszodi, N. ^{[1
]}

Valle, G. Avila ^{[3
,4
,5
]}

Barbarot, S. ^{[7
]}

Bieber, T. ^{[8
]}

Brough, H. A. ^{[9
,10
]}

Pinton, P. Calzavara ^{[11
]}

Christen-Zach, S. ^{[12
]}

Deleuran, M. ^{[13
]}

Dittmann, M. ^{[3
,4
,5
]}

Dressler, C. ^{[3
,4
,5
]}

Fink-Wagner, A. H. ^{[14
]}

Fosse, N. ^{[15
]}

Gaspar, K. ^{[16
]}

Gerbens, L. ^{[17
]}

Gieler, U. ^{[18
]}

Girolomoni, G. ^{[19
]}

Gregoriou, S. ^{[20
]}

Mortz, C. G. ^{[21
,22
]}

Nast, A. ^{[3
,4
,5
]}

Nygaard, U. ^{[23
]}

Redding, M. ^{[24
]}

Rehbinder, E. M. ^{[25
]}

Ring, J. ^{[26
]}

Rossi, M. ^{[27
]}

Serra-Baldrich, E. ^{[28
]}

Simon, D. ^{[29
]}

Szalai, Z. Z. ^{[30
]}

Szepietowski, J. C. ^{[31
]}

Torrelo, A. ^{[32
]}

Werfel, T. ^{[33
]}

Flohr, C. ^{[34
,35
]}

机构：

[1] Ludwig Maximilians Univ Munchen, Dept Dermatol & Allergy, Munich, Germany

[2] Vrije Univ Brussel VUB, Univ Ziekenhuis Brussel UZ Brussel, Dept Dermatol, Brussels, Belgium

[3] Charite Univ Med Berlin, Div Evidence Based Med dEBM, Dept Dermatol Venereol & Allergol, Berlin, Germany

[4] Free Univ Berlin, Berlin, Germany

[5] Humboldt Univ, Berlin, Germany

[6] European Federat Allergy & Airways Dis Patients A, Brussels, Belgium

[7] Nantes Univ, Dept Dermatol, INRAE, CHU Nantes,UMR 1280 PhAN, Nantes, France

[8] Univ Hosp Bonn, Dept Dermatol & Allergy, Bonn, Germany

[9] Guys & St Thomas NHS Fdn Trust, Childrens Allergy Serv, Evelina London Childrens Hosp, London, England

[10] Kings Coll London, Sch Life Course Sci, Dept Women & Childrens Hlth, London, England

[11] Univ Brescia, Dermatol Dept, Brescia, Italy

[12] Univ Hosp Lausanne, Lausanne, Switzerland

[13] Aarhus Univ Hosp, Aarhus, Denmark

[14] Global Allergy & Airways Dis Patient Platform GAA, Vienna, Austria

[15] Univ Hosp Basel, Dept Dermatol, Basel, Switzerland

[16] Univ Debrecen, Dept Dermatol, Debrecen, Hungary

[17] Amsterdam UMC Univ Med Ctr, Dept Dermatol, Amsterdam, Netherlands

[18] Univ Giessen, Dept Dermatol, Giessen, Germany

[19] Univ Verona, Dept Med, Dermatol & Venereol Sect, Verona, Italy

[20] Natl & Kapodistrian Univ Athens, Fac Med, Athens, Greece

[21] Univ Southern Denmark, Odense Univ Hosp, Dept Dermatol, Odense, Denmark

[22] Univ Southern Denmark, Odense Univ Hosp, Allergy Ctr, Odense, Denmark

[23] Aarhus Univ Hosp, Dept Dermatovenerol, Aarhus, Denmark

[24] Eczema Outreach Support UK, Linlithgow, Scotland

[25] Oslo Univ Hosp, Dermatol Dept, Oslo, Norway

[26] Tech Univ Munich, Dept Dermatol Allergol Biederstein, Munich, Germany

[27] Spedali Civili Hosp Brescia, Dermatol Unit, Brescia, Italy

[28] Hosp Santa Creu & Sant Pau, Dermatol, Barcelona, Spain

[29] Univ Bern, Bern Univ Hosp, Dept Dermatol, Inselspital, Bern, Switzerland

[30] Heim Pal Natl Childrens Inst Budapest, Pediat Dermatol Unit, Budapest, Hungary

[31] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland

[32] Hosp Infantil Nino Jesus, Madrid, Spain

[33] Hannover Med Sch, Hannover, Germany

[34] Kings Coll London, St Johns Inst Dermatol, London, England

[35] Guys & St Thomas NHS Fdn Trust, London, England

来源：

JOURNAL OF THE EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY | 2022年 / 36卷 / 09期

关键词：

atopic eczema; atopic dermatitis; DOUBLE-BLIND; TOPICAL CORTICOSTEROIDS; RHEUMATOID-ARTHRITIS; POSITION PAPER; TASK-FORCE; DERMATITIS; METHOTREXATE; PLACEBO; EFFICACY; SAFETY;

D O I：

10.1111/jdv.18345

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The evidence- and consensus-based guideline on atopic eczema was developed in accordance with the EuroGuiDerm Guideline and Consensus Statement Development Manual. Four consensus conferences were held between December 2020 and July 2021. Twenty-nine experts (including clinicians and patient representatives) from 12 European countries participated. This first part of the guideline includes general information on its scope and purpose, the health questions covered, target users and a methods section. It also provides guidance on which patients should be treated with systemic therapies, as well as recommendations and detailed information on each systemic drug. The systemic treatment options discussed in the guideline comprise conventional immunosuppressive drugs (azathioprine, ciclosporin, glucocorticosteroids, methotrexate and mycophenolate mofetil), biologics (dupilumab, lebrikizumab, nemolizumab, omalizumab and tralokinumab) and janus kinase inhibitors (abrocitinib, baricitinib and upadacitinib). Part two of the guideline will address avoidance of provocation factors, dietary interventions, immunotherapy, complementary medicine, educational interventions, occupational and psychodermatological aspects, patient perspective and considerations for paediatric, adolescent, pregnant and breastfeeding patients.

引用

页码：1409 / 1431

页数：23

共 50 条

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Kinberger, M.
Arents, B.
Aszodi, N.
Barbarot, S.
Bieber, T.
Brough, H. A.
Pinton, P. C.
Christen-Zaech, S.
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