METABOLISM, OXIDATION AND BIOLOGICAL IMPLICATIONS OF DOCOSAHEXAENOIC ACID IN NEURODEGENERATIVE DISEASES.

被引：5

作者：

Appolinario, Patricia Postilione ^{[1
]}

Mattos Cruz Derogis, Priscilla Bento ^{[1
]}

Yamaguti, Tatiana Harumi ^{[1
]}

Miyamoto, Sayuri ^{[1
]}

机构：

[1] Univ Sao Paulo, Inst Quim, Dept Bioquim, BR-05508900 Sao Paulo, Brazil

来源：

QUIMICA NOVA | 2011年 / 34卷 / 08期

关键词：

docosahexaenoic acid; metabolism; neurodegenerative diseases; AMYOTROPHIC-LATERAL-SCLEROSIS; POLYUNSATURATED FATTY-ACIDS; ALZHEIMERS-DISEASE; ALPHA-SYNUCLEIN; IN-VIVO; NEUROLOGICAL DISORDERS; SUPEROXIDE-DISMUTASE; LIPID HYDROPEROXIDE; BRAIN PHOSPHOLIPIDS; ARACHIDONIC-ACID;

D O I：

10.1590/S0100-40422011000800021

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

METABOLISM, OXIDATION AND BIOLOGICAL IMPLICATIONS OF DOCOSAHEXAENOIC ACID IN NEURODEGENERATIVE DISEASES. Docosahexaenoic acid (C22:6, n-3, DHA) is a polyunsaturated fatty acid (PUFA) present in large concentrations in the brain and, due to the presence of six double bonds in its structure, is highly susceptible to oxidation by enzymes and reactive oxygen/nitrogen species. The peroxidation of PUFAs has been implicated in an increasing number of human disorders, including neurodegenerative diseases. Hence, a better understanding of the metabolism pathways of DHA should provide new insights about its role in neurodegenerative diseases. Here we review the main aspects related to DHA metabolism, as well as, the recent findings showing its association with neurodegenerative diseases.

引用

页码：1409 / 1416

页数：8

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