Exploring 5-HT2 Receptors as Targets for Treating Epilepsy in Fragile X Syndrome: A Preclinical Study of Fmr1 Knock-out Mice

被引：0
|
作者：
Saraf, Tanishka [1 ]
Chen, Yiming [1 ]
Canal, Clinton [1 ]
机构：
[1] Mercer Univ, Macon, GA 31207 USA
来源：
FASEB JOURNAL | 2020年 / 34卷
关键词：
D O I：
10.1096/fasebj.2020.34.s1.05598
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
引用
收藏
页数：2
相关论文
共 28 条
  • [1] Sex Differences in an <it>Fmr1</it> Knock-out Mouse Model of Fragile X Syndrome
    Armstrong, Jessica
    Chen, Yiming
    Saraf, Tanishka
    Canal, Clinton
    FASEB JOURNAL, 2020, 34
  • [2] Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice
    Shuang Qiu
    Yu Wu
    Xinyou Lv
    Xia Li
    Min Zhuo
    Kohei Koga
    Molecular Brain, 11
  • [3] Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice
    Qiu, Shuang
    Wu, Yu
    Lv, Xinyou
    Li, Xia
    Zhuo, Min
    Koga, Kohei
    MOLECULAR BRAIN, 2018, 11
  • [4] Impaired sensorimotor gating in Fmr1 knock out and Fragile X premutation model mice
    Renoux, A. J.
    Sala-Hamrick, K. J.
    Carducci, N. M.
    Frazer, M.
    Halsey, K. E.
    Sutton, M. A.
    Dolan, D. F.
    Murphy, G. G.
    Todd, P. K.
    BEHAVIOURAL BRAIN RESEARCH, 2014, 267 : 42 - 45
  • [5] Transcriptional Dysregulation and Impaired Neuronal Activity in FMR1 Knock-Out and Fragile X Patients' iPSC-Derived Models
    Maussion, Gilles
    Rocha, Cecilia
    Abdian, Narges
    Yang, Dimitri
    Turk, Julien
    Valenzuela, Dulce Carrillo
    Pimentel, Luisa
    You, Zhipeng
    Morquette, Barbara
    Nicouleau, Michael
    Deneault, Eric
    Higgins, Samuel
    Chen, Carol X. -Q.
    Reintsch, Wolfgang E.
    Ho, Stanley
    Soubannier, Vincent
    Lepine, Sarah
    Modrusan, Zora
    Lund, Jessica
    Stephenson, William
    Schubert, Rajib
    Durcan, Thomas M.
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (19)
  • [6] Evaluation of Serotonin 5-HT1A, 5-HT2A, and 5-HT2C Receptors and the Serotonin Transporter in an Fmr1 Knockout Mouse Model of Fragile X Syndrome
    Saraf, Tanishka
    Chen, Yiming
    Armstrong, Jessica
    Prophitt, Jennifer
    Canal, Clinton
    FASEB JOURNAL, 2021, 35
  • [7] Targeting 5-HT1A Receptors to Correct Perineuronal Net and Social Behavioral Deficits in Fmr1 Knockout Mice, a Model of Fragile X Syndrome
    Armstrong, Jessica L.
    Canal, Clinton E.
    FASEB JOURNAL, 2022, 36
  • [8] Role of 5-HT1A receptors in the regulation of sleep and wakefulness. Study in 5-HT1A knock-out mice
    Boutrel, B
    Monaca, C
    Hen, R
    Hamon, M
    Adrien, J
    SLEEP, 2001, 24 : A146 - A147
  • [9] Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors
    Popa, D
    Léna, C
    Fabre, V
    Prenat, C
    Gingrich, J
    Escourrou, P
    Hamon, M
    Adrien, J
    JOURNAL OF NEUROSCIENCE, 2005, 25 (49): : 11231 - 11238
  • [10] Evaluation of Perineuronal Nets and Their Regulation by Serotonin 5-HT7 Receptors in a Juvenile Fmr1 Knockout Mouse Model of Fragile X Syndrome
    Armstrong, Jessica
    Gash, Kyle
    Canal, Clinton
    FASEB JOURNAL, 2021, 35
123