Time-dependent changes in the plasma amino acid concentration in diabetes mellitus

被引：29

作者：

Mochida, Taiga ^{[1
]}

Tanaka, Takayuki ^{[2
]}

Shiraki, Yasuko ^{[1
]}

Tajiri, Hiroko ^{[1
]}

Matsumoto, Shirou ^{[1
]}

Shimbo, Kazutaka ^{[2
]}

Ando, Toshihiko ^{[3
]}

Nakamura, Kimitoshi ^{[1
]}

Okamoto, Masahiro ^{[4
]}

Endo, Fumio ^{[1
]}

机构：

[1] Kumamoto Univ, Grad Sch Med Sci, Dept Pediat, Kumamoto 8608556, Japan

[2] AJINOMOTO Co Inc, Inst Innovat, Frontier Res Labs, Kawasaki Ku, Kanagawa 2108681, Japan

[3] AJINOMOTO Co Inc, Hlth Informat Dept, Chuo Ku, Tokyo 1048315, Japan

[4] Kyushu Univ, Dept Bioinformat, Grad Sch Syst Life Sci, Higashi Ku, Fukuoka 8128582, Japan

来源：

MOLECULAR GENETICS AND METABOLISM | 2011年 / 103卷 / 04期

关键词：

AKITA mouse; Insulin deficiency; Diabetes mellitus; Plasma amino acid; Longitudinal change; BRANCHED-CHAIN AMINO; INSULIN; ALANINE; DYSFUNCTION; METABOLISM; STARVATION; LEUCINE; MODY;

D O I：

10.1016/j.ymgme.2011.05.002

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We investigated longitudinal change in the amino acid (AA) profile in type 1 diabetes mellitus (DM) using AKITA mice, which develop DM as a result of insulin deficiency. The plasma concentrations of valine, leucine, isoleucine, as well as the total branched chain amino acids, alanine, citrulline and proline, were significantly higher in the diabetic mice. We show that the degree and timing of the changes were different among the plasma amino acid concentrations (pAAs) during the development of type 1 DM. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：406 / 409

页数：4

共 50 条

[1] Time-Dependent Changes of Urethral Function in Diabetes Mellitus: A Review
Cao, Nailong
Gu, Baojun
Gotoh, Daisuke
Yoshimura, Naoki
[J]. INTERNATIONAL NEUROUROLOGY JOURNAL, 2019, 23 (02) : 91 - 99
[2] Time-dependent changes in the plasma concentration of matrix metalloproteinase 9 after acute myocardial infarction
Kaden, JJ
Dempfle, CE
Sueselbeck, T
Brueckmann, M
Poerner, TC
Haghi, D
Haase, KK
Borggrefe, M
[J]. CARDIOLOGY, 2003, 99 (03) : 140 - 144
[3] EFFECT OF DIETARY PROTEINS ON TIME-DEPENDENT CHANGES IN PLASMA AMINO-ACID LEVELS AND ON LIVER PROTEIN-SYNTHESIS IN RATS
GALIBOIS, I
PARENT, G
SAVOIE, L
[J]. JOURNAL OF NUTRITION, 1987, 117 (12): : 2027 - 2035
[4] Dose- and time-dependent pharmacokinetics of midostaurin in patients with diabetes mellitus
Wang, Yanfeng
Yin, Ophelia Q. R.
Graf, Peter
Kisicki, James C.
Schran, Horst
[J]. JOURNAL OF CLINICAL PHARMACOLOGY, 2008, 48 (06): : 763 - 775
[5] TIME-DEPENDENT CONFIGURATION CHANGES OF THE MAGNETOTAIL AND PLASMA SHEET THINNING
MURPHY, CH
[J]. PLANETARY AND SPACE SCIENCE, 1979, 27 (02) : 103 - 112
[6] Quick responses of plasma amino acid concentration to changes in dietary amino acid levels in rats
Watanabe, R
Iizuka, T
Kokawa, K
Yamamoto, A
Ishibashi, T
[J]. EXPERIMENTAL ANIMALS, 1998, 47 (01) : 37 - 42
[7] Bayesian forecasting of plasma vancomycin concentration using time-dependent pharmacokinetics
Nakamura, T
Wakaki, N
Kimura, Y
Goto, N
Masada, M
[J]. YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1996, 116 (11): : 876 - 883
[8] Time-dependent irisin concentration changes in patients affected by overt hypothyroidism
Zybek-Kocik, Ariadna
Sawicka-Gutaj, Nadia
Wrotkowska, Elzbieta
Sowinski, Jerzy
Ruchala, Marek
[J]. ENDOKRYNOLOGIA POLSKA, 2016, 67 (05) : 476 - 480
[9] Concentration- and time-dependent effect of aminooxyacetic acid on cortical epileptogenicity
Barna, B
Szász, A
Asztalos, T
Szupera, Z
Vécsei, L
Houtzager, H
Szente, M
[J]. ACTA BIOLOGICA HUNGARICA, 2002, 53 (03): : 245 - 256
[10] Concentration- and Time-Dependent Effect of Aminooxyacetic Acid on Cortical Epileptogenicity
Barbara Barna
A. Szász
T. Asztalos
Z. Szupera
L. Vécsei
Helmi Houtzager
Magdolna Szente
[J]. Acta Biologica Hungarica, 2002, 53 : 245 - 256

← 1 2 3 4 5 →