The role of ethyl glucuronide in supporting medico-legal investigations: Analysis of this biomarker in different postmortem specimens from 21 selected autopsy cases

被引：11

作者：

Santunione, Anna Laura ^{[1
]}

Verri, Patrizia ^{[1
]}

Marchesi, Filippo ^{[1
]}

Rustichelli, Cecilia ^{[2
]}

Palazzoli, Federica ^{[1
]}

Vandelli, Daniele ^{[1
]}

Licata, Manuela ^{[1
]}

Silingardi, Enrico ^{[1
]}

机构：

[1] Univ Modena & Reggio Emilia, Div Legal Med, Dept Diagnost Med Clin & Publ Hlth, Via Pozzo 71, I-41124 Modena, Italy

[2] Univ Modena & Reggio Emilia, Dept Life Sci, Via G Campi 103, I-41125 Modena, Italy

来源：

JOURNAL OF FORENSIC AND LEGAL MEDICINE | 2018年 / 53卷

关键词：

Alcohol consumption; Ethyl glucuronide; LC-MS/MS; Autopsy samples; MASS-SPECTROMETRY; BLOOD; URINE; REDISTRIBUTION; INGESTION; SULFATE; ETHANOL; MARKER; LIVER; HAIR;

D O I：

10.1016/j.jflm.2017.10.009

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

Ethanol determination in postmortem blood is one of the most frequently requested analyses in legal medicine and forensic toxicology. Ethyl glucuronide is a non-oxidative ethanol metabolite. It is also a useful marker of ante-mortem alcohol ingestion when ethanol itself has been completely eliminated from the body and could be considered in autopsy cases to obtain more reliable indications. The aim of the present study was to investigate the ethyl glucuronide distribution in postmortem specimens from autopsy cases found to be positive for ethanol. We presented 21 autopsy cases in which central blood, peripheral blood and liver samples were available. Specimens were analyzed for ethyl glucuronide by liquid chromatography tandem mass spectrometry; we also recorded postmortem interval, case history, cause of death, use of drugs, metabolic disorders if present, putrefaction if present, history of ethanol abuse and information about ethanol intake before death. Our aim was to evaluate and to compare the ethyl glucuronide levels in different matrices taken from the same subject in order to provide a better understanding of the interpretation of postmortem ethyl glucuronide concentrations.

引用

页码：25 / 30

页数：6