Bisoprolol for congestive heart failure

被引：3
|
作者：
Rosenberg, Jens [1 ]
Gustafsson, Finn [2 ]
机构：
[1] Frederiksberg Univ Hosp, Dept Cardiol, DK-2000 Copenhagen, Denmark
[2] Rigshosp, Dept Cardiol, DK-2100 Copenhagen, Denmark
来源：
EXPERT OPINION ON PHARMACOTHERAPY | 2008年 / 9卷 / 02期
关键词：
absorption; administration and dosage; adrenergic beta-antagonist; biological availability; bisoprolol; blood pressure; half-life; heart failure; heart rate; metabolism; pharmacokinetics;
D O I：
10.1517/14656566.9.2.293
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Background: beta-Blockers are a cornerstone in the treatment of systolic heart failure treatment, but not all beta-blockers are effective or in this setting. Objective: To define the role of bisoprolol, a highly selective beta(1)-antagonist in congestive heart failure due to systolic dysfunction. Methods: Using the keywords 'bisoprolol' and 'heart failure' PubMed and BIOSIS databases were searched for information regarding pharmacology and relevant randomised clinical trials. Supplementary publications were acquired by scrutinising reference lists of relevant papers. Additional information was obtained from the FDA website. Conclusion: Bisoprolol is an effective and well-tolerated first-line beta-blocker for patients with systolic heart failure. The knowledge is primarily based on study patients with moderate-to-severe heart failure from the three CIBIS trials.
引用
收藏
页码：293 / 300
页数：8
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