Lanthanide-containing polymer nanoparticles for biological tagging applications: Nonspecific endocytosis and cell adhesion

被引：70
|
作者：
Vancaeyzeele, Cedric
Ornatsky, Olga
Baranov, Vladimir
Shen, Lei
Abdelrahman, Ahmed
Winnik, Mitchell A.
机构：
[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada
[2] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 44期
关键词：
D O I：
10.1021/ja073970w
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We describe the synthesis and characterization of element-encoded polystyrene nanoparticles with diameters on the order of 100 nm and a narrow size distribution. Individual particles contain ca. 10(3) chelated lanthanide ions, of either a single element or a mixture of elements. These particles were effectively internalized by nonspecific endocytosis into three cell lines associated with human leukemia. Using an assay based upon ICP-MS detection, we could monitor quantitatively cell adhesion induced by cell differentiation of THP-1 cells in response to phorbol ester stimulation (PMA) in single cell type or mixed cultures.
引用
收藏
页码：13653 / 13660
页数：8
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