Effect of Source Geometry on Interdependent Calcium and Inositol 1; 4; 5-Trisphosphate Dynamics in a Cardiac Myocyte Cell

Intracellular calcium governs the most versatile and universal signalling mechanism in living systems which includes contraction of the cardiac tissues, information processing in the brain, release of digestive enzymes by the liver etc. Various investigations have been made on study of calcium signalling in cardiac myocyte to understand its mechanisms. But most of existing investigations have mainly focused on study of calcium signalling in cardiac myocyte cell without paying attention on interdependence of calcium signalling and inositol 1; 4; 5-trisphosphate signalling. In this paper, we propose a mathematical model to understand the impact of the source geometry of calcium on these coupled signalling processes. This study suggests that the source geometry plays a vital role in these signalling processes. Also, calcium and inositol 1; 4; 5-trisphosphate shows a beautiful coordination with each other, which explains the role of inositol 1; 4; 5-trisphosphate in calcium signalling in cardiac myocyte cell. Such studies will provide the better understanding of various factors involved in calcium signalling in cardiac myocytes, which as a result will be of great use to biomedical scientists for making protocols for various heart diseases and their cure.