Ceruloplasmin expression in renal cell carcinoma correlates with higher-grade and shortened survival

被引：1
|
作者：
Zimpfer, Annette [1 ]
Glass, Aenne [2 ]
Bastian, Manuela [3 ]
Schuff-Werner, Peter [3 ]
Hakenberg, Oliver W. [4 ]
Maruschke, Matthias [4 ,5 ]
机构：
[1] Univ Med Rostock, Inst Pathol, Strempelstr 14, D-18055 Rostock, Germany
[2] Univ Med Rostock, Inst Biostat & Informat Med, Ernst Heydemann Str 8, D-18057 Rostock, Germany
[3] Univ Med Rostock, Inst Clin Chem & Lab Med, Ernst Heydemann Str 6, D-18057 Rostock, Germany
[4] Univ Med Rostock, Dept Urol, Ernst Heydemann Str 8, D-18057 Rostock, Germany
[5] HELIOS Hanseklinikum Stralsund, Dept Urol, Grosse Parower Str 47-53, D-18435 Stralsund, Germany
来源：
BIOMARKERS IN MEDICINE | 2021年 / 15卷 / 11期
关键词：
biofluid analysis; ceruloplasmin; prognosis; renal cell carcinoma; serum biomarker; tissue biomarker; urine biomarker; RECEPTOR; TUMORS; IDENTIFICATION; ACTIVATION; PROTEINS; GENES;
D O I：
10.2217/bmm-2020-0514
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: We aimed to explore ceruloplasmin (CP) expression in clear cell renal cell carcinoma (ccRCC). Materials & methods: CP was analyzed in biofluid samples of 63 ccRCC patients, divided into three grading groups, and immunohistochemically, in 308 ccRCC. Results: Significant differences of mean plasma and urine CP levels in different grading groups were found. CP immunoreactivity was significantly linked to high-grade disease. Log rank tests showed a significant shorter overall survival rate in CP-positive cases (all p < 0.05). Conclusion: CP protein levels in biofluid samples confirmed differential CP expressions, depending on nuclear grade in ccRCC as previously seen in RNA expression analysis. CP expression was linked to high-grade disease and reduced survival rate in RCC.
引用
收藏
页码：841 / 850
页数：10
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