Infections in HIV-infected patients with malignancy

With the increasing prevalence of HIV, better combination treatment regimens, and preventive therapy for opportunistic infections, physicians will be caring for an ever-increasing number of survivors with an ever-dwindling immune function. Increasing this burden is the unfortunate patient who also develops cancer concurrent with HIV infection. The combined risk factors of these diseases make a worst-case scenario in evaluation and treatment of infections. This article reviews AIDS-defining tumors and other malignancies, risk factors for infection, opportunistic infections, and therapy strategies.