Erectile dysfunction in prostate cancer patients treated with intensity-modulated radiation therapy

被引:5
|
作者
Yildirim, Halil Cumhur [1 ]
Ergen, Sefika Arzu [1 ]
Sedef, Emine [1 ]
Sahin, Merve [1 ]
Karacam, Songul Cavdar [1 ]
Senocak, Mustafa Sukru [2 ]
Dincbas, Fazilet Oner [1 ]
机构
[1] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Radiat Oncol, Istanbul, Turkey
[2] Istanbul Univ Cerrahpasa, Cerrahpasa Med Fac, Dept Biostat, Istanbul, Turkey
关键词
Erectile dysfunction; intensity modulated radiotherapy; penile bulb; prostate cancer; 3-DIMENSIONAL CONFORMAL RADIOTHERAPY; QUALITY-OF-LIFE; PENILE BULB; SEXUAL FUNCTION; BRACHYTHERAPY; IMPOTENCE; RISK; MEN;
D O I
10.4103/ijc.IJC_465_18
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background: Sexual dysfunction is an important side-effect after radiotherapy (RT) for prostate cancer (PCa). The aim of this study was to compare sexual functions of PCa patients before and after intensity-modulated RT and to analyze their correlation with penile bulb (PB) doses and patient characteristics. Materials and Methods: Forty-two patients who underwent RT +/- hormone therapy for PCa between 2010 and 2013 were analyzed. Sexual functions assessed by patient-reported questionnaire and physician reported scale before and 3 years after treatment. The effect of patients' age, prostate volume, testosterone levels, comorbidity, smoking status, tumor stage, RT technique, hormone therapy, and PB doses to sexual functions were investigated. Results: After 3 years of RT, 64.3% of all patients had a lower erectile score; and 75% of patients who were previously potent (n = 24) had become impotent after treatment. However sexual desire still remained in 75.8% of patients who had desire before treatment (n = 33). Statistical analysis showed that two parameters were correlated with postradiotherapy impotency outcome; PB mean radiation dose (P = 0.033) and testosterone levels (P = 0.032). Conclusions: RT, despite modern techniques, affects the sexual function of PCa patients in varying degrees. Reducing radiation doses to penile structures may play a role in preventing erectile dysfunction.
引用
收藏
页码:70 / 75
页数:6
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