Preclinical models for chemoprevention of colon cancer

被引：0
|
作者：
Gerner, EW [1 ]
Ignatenko, NA [1 ]
Besselsen, DG [1 ]
机构：
[1] Univ Arizona, Tucson, AZ 85724 USA
来源：
TUMOR PREVENTION AND GENETICS | 2003年 / 163卷
关键词：
cell and rodent models; colon cancer; chemoprevention; inherited intestinal cancer syndromes;
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Colon cancer is the second leading cause of cancer incidence and death in the USA in 2002. Specific genetic defects have been identified which cause hereditary colon cancers in humans. In addition, a number of intestinal luminal risk factors for colon cancer have been described. This information has been exploited to develop experimental cell and rodent models which recapitulate features of human colon cancer. In this chapter, we will discuss the strengths and limitations of these models to further our understanding of basic mechanisms of colon carcinogenesis and to develop strategies for colon cancer chemoprevention.
引用
收藏
页码：58 / 71
页数：14
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