Stochastic bursts in the kinetics of gene expression with regulation by long non-coding RNAs

被引：5
|
作者：
Zhdanov, V. P. [1 ,2 ]
机构：
[1] Chalmers, Dept Appl Phys, S-41296 Gothenburg, Sweden
[2] Russian Acad Sci, Boreskov Inst Catalysis, Novosibirsk 630090, Russia
来源：
JETP LETTERS | 2010年 / 92卷 / 06期
关键词：
DISTINCT MESSENGER-RNAS; NONPROTEIN CODING RNA; BISTABLE KINETICS; ESCHERICHIA-COLI; INTRINSIC NOISE; TRANSCRIPTION; PROTEIN; BISTABILITY; MICRORNAS; CONSEQUENCES;
D O I：
10.1134/S0021364010180104
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
One of the main recent breakthroughs in cellular biology is a discovery of numerous non-coding RNAs (ncR-NAs). We outline abilities of long ncRNAs and articulate that the corresponding kinetics may frequently exhibit stochastic bursts. For example, we scrutinize one of the generic cases when the gene transcription is regulated by competitive attachment of ncRNA and protein to a regulatory site. Our Monte Carlo simulations show that in this case one can observe huge long transcriptional bursts consisting of short bursts.
引用
收藏
页码：410 / 415
页数：6
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