The Development of FtsZ Inhibitors as Potential Antibacterial Agents

被引：50

作者：

Ma, Siti ^{[1
]}

Ma, Shutao ^{[1
]}

机构：

[1] Shandong Univ, Dept Med Chem, Key Lab Chem Biol, Minist Educ,Sch Pharmaceut Sci, Jinan 250012, Peoples R China

来源：

CHEMMEDCHEM | 2012年 / 7卷 / 07期

基金：

中国国家自然科学基金;

关键词：

biological activity; FtsZ; inhibitors; mechanisms of action; synthetic methods; BACTERIAL-CELL-DIVISION; PRODUCTS TARGETING FTSZ; PROTEIN FTSZ; MYCOBACTERIUM-TUBERCULOSIS; ASSEMBLY DYNAMICS; FLUORESCENT-PROBE; CRYSTAL-STRUCTURE; SMALL-MOLECULE; IN-VITRO; TUBULIN;

D O I：

10.1002/cmdc.201200156

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The emergence and prevalence of bacterial resistance has resulted in a clear demand for novel antibacterial drugs. As a tubulin homologue, FtsZ is an essential cell-division protein in prokaryotic organisms and is showing increasing promise as a target for antibacterial drug discovery. This review describes the role of FtsZ in bacterial cytokinesis and various FtsZ inhibitors, with particular focus on their discovery, antibacterial activities, mechanisms of action, synthetic methods, and representative analogues.

引用

页码：1161 / 1172

页数：12

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