Repurposing of Kinase Inhibitors as Broad-Spectrum Antiviral Drugs

被引：65
|
作者：
Schor, Stanford [1 ,2 ]
Einav, Shirit [1 ,2 ]
机构：
[1] Dept Med, Div Infect Dis & Geog Med, Stanford, CA USA
[2] Stanford Univ, Sch Med, Dept Microbiol & Immunol, Stanford, CA 94305 USA
来源：
DNA AND CELL BIOLOGY | 2018年 / 37卷 / 02期
关键词：
kinase inhibitors; antiviral drugs; repurposing; broad-spectrum antivirals; HEPATITIS-C VIRUS; GROWTH-FACTOR RECEPTOR; CYCLIN-DEPENDENT KINASES; DENGUE VIRUS; HOST FACTORS; IN-VITRO; ENTRY; INFECTION; IDENTIFICATION; REPLICATION;
D O I：
10.1089/dna.2017.4033
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The high cost of drug development and the narrow spectrum of coverage typically provided by direct-acting antivirals limit the scalability of this antiviral approach. This review summarizes progress and challenges in the repurposing of approved kinase inhibitors as host-targeted broad-spectrum antiviral therapies.
引用
收藏
页码：63 / 69
页数：7
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