The SDF-1/CXCR4 axis in stem cell preconditioning

被引：117
|
作者：
Cencioni, Chiara [2 ]
Capogrossi, Maurizio C. [1 ]
Napolitano, Monica [1 ]
机构：
[1] Ist Dermopat Immacolata IRCCS, Lab Patol Vasc, I-00167 Rome, Italy
[2] Ctr Cardiol Monzino IRCCS, Lab Biol Vasc & Med Rigenerat, I-20138 Milan, Italy
来源：
CARDIOVASCULAR RESEARCH | 2012年 / 94卷 / 03期
关键词：
SDF-1; CXCR4; Ischaemia; Preconditioning; ENDOTHELIAL PROGENITOR CELLS; CHEMOKINE RECEPTOR CXCR4; ACUTE MYOCARDIAL-INFARCTION; NITRIC-OXIDE-SYNTHASE; HYPOXIA-INDUCIBLE FACTOR-1; LEFT-VENTRICULAR FUNCTION; BONE-MARROW; GROWTH-FACTOR; ISCHEMIC CARDIOMYOPATHY; MONONUCLEAR-CELLS;
D O I：
10.1093/cvr/cvs132
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We review the pivotal role of the stromal derived factor (SDF)-1 chemokine in tissue ischaemia and how it orchestrates the rapid revascularization of injured, ischaemic, and regenerating tissues via the CXC chemokine receptors CXCR4 and CXCR7. Furthermore, we discuss the effects of preconditioning (PC), which is a well-known protective phenomenon for tissue ischaemia. The positive effect of both hypoxic and acidic PC on progenitor cell therapeutic potential is reviewed, while stressing the role of the SDF-1/CXCR4 axis in this process.
引用
收藏
页码：400 / 407
页数：8
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