Enantioselective Conjugate Additions of α-Amino Radicals via Cooperative Photoredox and Lewis Acid Catalysis

被引：194
|
作者：
Espelt, Laura Ruiz [1 ]
McPherson, Iain S. [1 ]
Wiensch, Eric M. [1 ]
Yoon, Tehshik P. [1 ]
机构：
[1] Univ Wisconsin, Dept Chem, Madison, WI 53706 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2015年 / 137卷 / 07期
关键词：
PHOTOINDUCED ELECTRON-TRANSFER; LIGHT-MEDIATED ADDITION; VISIBLE-LIGHT; PHOTOCHEMICAL-REACTIONS; MERGING PHOTOREDOX; MICHAEL ACCEPTORS; DUAL-CATALYSIS; CYCLIZATION; ORGANOCATALYSIS; DESILYLATION;
D O I：
10.1021/ja512746q
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We report the highly enantioselective addition of photogenerated alpha-amino radicals to Michael acceptors. This method features a dual-catalyst protocol that combines transition metal photoredox catalysis with chiral Lewis acid catalysis. The combination of these two powerful modes of catalysis provides an effective, general strategy to generate and control the reactivity of photogenerated reactive intermediates.
引用
收藏
页码：2452 / 2455
页数：4
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