Safety of sunitinib in patients with renal cell carcinoma following nephrectomy

被引：1
|
作者：
Heraudet, Luc [1 ]
Domblides, Charlotte [1 ,2 ]
Daste, Amaury [1 ]
Lefort, Felix [1 ]
Bernhard, Jean-Christophe [3 ]
Ravaud, Alain [1 ,2 ]
Gross-Goupil, Marine [1 ]
机构：
[1] Bordeaux Univ Hosp, Dept Med Oncol, St Andre, France
[2] Univ Bordeaux, Bordeaux, France
[3] Bordeaux Univ Hosp, Dept Urol, Bordeaux, France
来源：
EXPERT OPINION ON DRUG SAFETY | 2020年 / 19卷 / 07期
关键词：
Sunitinib; clear cell carcinoma; metastatic; safety; adjuvant; HIGH-RISK; ADJUVANT SUNITINIB; SORAFENIB; MANAGEMENT; THERAPY; HYPERTENSION; MALATE; ASSURE;
D O I：
10.1080/14740338.2020.1774551
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Introduction The safety profile characteristics of sunitinib were evaluated in patients who underwent nephrectomy for kidney cancer. Areas covered In this literature review, safety data were evaluated from phase III trials investigating sunitinib following nephrectomy, either in the more recent adjuvant setting after nephrectomy or in the metastatic setting, with a focus on new data from the CARMENA and SURTIME trials. In particular, the aim was to determine the specificity of toxicity in the adjuvant setting. Expert opinion In the adjuvant setting, even if the toxicity profile of sunitinib does not differ significantly from that in the metastatic setting, the importance of the dose intensity and, thus, exposure has been emphasized. Consequently, as described mainly in the metastatic setting, management of the adverse effects of sunitinib remains critical.
引用
收藏
页码：799 / 806
页数：8
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