Angiogenic activity of multiple myeloma endothelial cells in vivo in the chick embryo chorioallantoic membrane assay is associated to a down-regulation in the expression of endogenous endostatin

被引：22
|
作者：
Mangieri, Domenica [1 ]
Nico, Beatrice [1 ]
Benagiano, Vincenzo [1 ]
De Giorgis, Michela [1 ]
Vacca, Angelo [2 ]
Ribatti, Domenico [1 ]
机构：
[1] Univ Bari, Sch Med, Dept Human Anat & Histol, I-70124 Bari, Italy
[2] Univ Bari, Sch Med, Dept Biomed Sci & Human Oncol, I-70124 Bari, Italy
来源：
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2008年 / 12卷 / 03期
关键词：
angiogenesis; endostatin; chorioallantoic membrane; multiple myeloma;
D O I：
10.1111/j.1582-4934.2008.00152.x
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We have attempted a fine characterization of the angiogenic response induced by multiple myeloma endothelial cells (MMEC) by using the chick embryo chorioallantoic membrane (CAM) assay and by reverse transcriptase-polymerase chain reaction (RT-PCR). Results showed that in the CAM assay MMEC induced an angiogenic response comparable to that of a well-known angiogenic cytokine, namely fibroblast growth factor-2 (FGF-2), while RT-PCR demonstrated that the expression of endostatin mRNA detected in MM treated CAM was significantly lower respect to control CAM. These data suggest that angiogenic switch in MM may involve loss of an endogenous angiogenesis inhibitor, such as endostatin.
引用
收藏
页码：1023 / 1028
页数：6
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