Hypoxia-induced signaling in the cardiovascular system

被引：54
|
作者：
Simon, M. Celeste [1 ,2 ]
Liu, Liping [1 ,2 ]
Barnhart, Bryan C. [1 ]
Young, Regina M. [1 ]
机构：
[1] Univ Penn, Abramson Family Canc Res Inst, Philadelphia, PA 19104 USA
[2] Univ Penn, Howard Hughes Med Inst, Philadelphia, PA 19104 USA
来源：
ANNUAL REVIEW OF PHYSIOLOGY | 2008年 / 70卷
关键词：
oxygen; transcription; translation; stress responses;
D O I：
10.1146/annurev.physiol.70.113006.100526
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Low oxygen (O-2) levels are a naturally occurring feature of embryonic development, adult physiology, and diseases such as those of the cardiovascular system. Although many responses to O-2 deprivation are mediated by hypoxia-inducible factors (HIFs), researchers are finding a growing number of HIF-independent pathways that promote O-2 conformance and hypoxia tolerance. Here, we describe HIF-independent responses and how they impact cardiovascular tissue homeostasis.
引用
收藏
页码：51 / 71
页数：21
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