A Therapeutic Target for Smoking-Associated Lung Cancer

被引：17
|
作者：
Turner, Nicholas C. [1 ,2 ]
Seckl, Michael J. [3 ]
机构：
[1] Royal Marsden Hosp, London SW3 6JJ, England
[2] Inst Canc Res, Breakthrough Breast Canc Res Ctr, London SW3 6JB, England
[3] Univ London Imperial Coll Sci Technol & Med, CR UK Labs, Lung Canc Biol Grp, London W12 0NN, England
来源：
SCIENCE TRANSLATIONAL MEDICINE | 2010年 / 2卷 / 62期
关键词：
FIBROBLAST-GROWTH-FACTOR; POLYMORPHISM ARRAY ANALYSIS; MONOCLONAL-ANTIBODY; BREAST-CANCER; FGFR1; AMPLIFICATIONS; TUMORS; ADENOCARCINOMA; INHIBITION; CARCINOMAS;
D O I：
10.1126/scitranslmed.3001942
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
A report in this issue of Science Translational Medicine reveals that amplification of the FGFR1 gene-which encodes fibroblast growth factor receptor 1-is a major oncogenic aberration in squamous cell lung cancer. This genetic variation may represent the first relatively high-frequency therapeutic target of smoking-associated lung cancer.
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页数：4
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