CD8+ Resident Memory T Cells and Viral Infection

被引：43
|
作者：
Wu, Xuejie [1 ]
Wu, Pin [2 ]
Shen, Yifei [3 ]
Jiang, Xiaodong [3 ]
Xu, Feng [1 ]
机构：
[1] Zhejiang Univ, Dept Infect Dis, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China
[2] Zhejiang Univ, Dept Thorac Surg, Affiliated Hosp 2, Sch Med, Hangzhou, Zhejiang, Peoples R China
[3] Yale Univ, Sch Med, Dept Immunobiol, New Haven, CT USA
来源：
FRONTIERS IN IMMUNOLOGY | 2018年 / 9卷
基金：
中国国家自然科学基金;
关键词：
memory T cells; tissue-resident memory T cells; microenvironment; viral infection; immune response; TISSUE-RESIDENT; CUTTING EDGE; RECALL RESPONSES; PROMOTES DIFFERENTIATION; NONLYMPHOID TISSUES; VIRUS-INFECTION; LOCAL ANTIGEN; TGF-BETA; RM CELLS; EFFECTOR;
D O I：
10.3389/fimmu.2018.02093
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Tissue-resident memory T (Trm) cells are a subset of recently identified memory T cells that mainly reside and serve as sentinels in non-lymphoid peripheral tissues. Unlike the well-characterized circulating central memory T (Tcm) cells and effector memory T (Tem) cells, Trm cells persist in the tissues, do not recirculate into blood, and offer immediate protection against pathogens upon reinfection. In this review, we focus on CD8(+) Trm cells and briefly introduce their characteristics, development, maintenance, and function during viral infection. We also discuss some unresolved problems, such as how CD8(+) Trm cells adapt to the local tissue microenvironment, how Trm cells interact with other immune cells during their development and maintenance, and the mechanisms by which CD8(+) Trm cells confer immune protection. We believe that a better understanding of these problems is of great clinical and therapeutic value and may contribute to more effective vaccination and treatments against viral infection.
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页数：9
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