Potentiation of N-methyl-D-aspartate currents by isoproterenol in the acutely dissociated rat amygdalar neurons

被引：16
|
作者：
Huang, CC [1 ]
Lin, CH [1 ]
Gean, PW [1 ]
机构：
[1] Natl Cheng Kung Univ, Coll Med, Dept Pharmacol, Tainan 701, Taiwan
来源：
NEUROSCIENCE LETTERS | 1998年 / 253卷 / 01期
关键词：
isoproterenol; N-methyl-D-aspartate receptor; amygdala; forskolin; protein kinase A;
D O I：
10.1016/S0304-3940(98)00571-0
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Whole-cell patch-clamp recordings in the acutely dissociated amygdalar neurons were performed to investigate the effect of isoproterenol (Iso) on NMDA currents. Bath application of Iso selectively enhanced the NMDA currents without affecting the AMPA currents. Iso potentiated the NMDA currents to the same extent at various holding potentials and the reversal potential for the NMDA response was not altered. These results suggest that adrenergic innvervations in this area may play an important role in synaptic plasticity.
引用
收藏
页码：9 / 12
页数：4
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