Measurement of damage in systemic vasculitis: a comparison of the Vasculitis Damage Index with the Combined Damage Assessment Index

被引:40
|
作者
Suppiah, Ravi [1 ]
Flossmann, Oliver [2 ]
Mukhtyar, Chetan [3 ]
Alberici, Federico [4 ]
Baslund, Bo [5 ]
Brown, Denise [1 ]
Hasan, Nadeem [1 ]
Holle, Julia [6 ]
Hruskova, Zdenka [7 ,8 ]
Jayne, David [2 ]
Judge, Andrew [9 ]
Little, Mark A. [10 ]
Merkel, Peter A. [11 ]
Palmisano, Alessandra [4 ]
Seo, Philip [12 ]
Stegeman, Coen [13 ]
Tesar, Vladimir [7 ,8 ]
Vaglio, Augusto [4 ]
Westman, Kerstin [14 ]
Luqmani, Raashid [1 ,9 ]
机构
[1] Nuffield Orthopaed Ctr, Dept Rheumatol, Oxford OX3 7LD, England
[2] Addenbrookes Hosp, Dept Nephrol, Cambridge, England
[3] Norfolk & Norwich Univ Hosp, Dept Rheumatol, Norwich, Norfolk, England
[4] Univ Parma, Dept Nephrol, I-43100 Parma, Italy
[5] Univ Hosp Copenhagen, Copenhagen, Denmark
[6] Univ Hosp Schleswig Holstein, Dept Rheumatol, Vasculitis Ctr, Lubeck, Germany
[7] Fac Med 1, Prague, Czech Republic
[8] Gen Teaching Hosp, Prague, Czech Republic
[9] Univ Oxford, NIHR Musculoskeletal BRU, Nuffield Dept Orthopaed Rheumatol & Musculoskelet, Oxford, England
[10] UCL, Ctr Nephrol, London, England
[11] Boston Univ, Vasculitis Ctr, Boston, MA 02215 USA
[12] John Hopkins Vasculitis Ctr, Baltimore, MD USA
[13] Univ Groningen, Univ Med Ctr Groningen, NL-9713 AV Groningen, Netherlands
[14] Univ Hosp MAS, Malmo, Sweden
基金
美国国家卫生研究院;
关键词
ANTIBODY-ASSOCIATED VASCULITIS; TERM-FOLLOW-UP; WEGENERS-GRANULOMATOSIS; RANDOMIZED-TRIAL; MICROSCOPIC POLYANGIITIS; POLYARTERITIS-NODOSA; OUTCOME MEASURES; PLASMA-EXCHANGE; CYCLOPHOSPHAMIDE; THERAPY;
D O I
10.1136/ard.2009.122952
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives To compare the Vasculitis Damage Index (VDI) with the Combined Damage Assessment Index (CDA) as measures of damage from vasculitis. Methods A total of 283 patients with vasculitis from 11 European centres were evaluated in a cross-sectional study using the VDI and CDA. Results Wegener's granulomatosis (58.4%) and microscopic polyangiitis (11.0%) were the most common diagnoses. Agreement between VDI and CDA scores (Spearman's correlation) was 0.90 (95% CI 0.87 to 0.92). There was good correlation between individual comparably evaluated organ systems (Spearman's correlation 0.70-0.94). Interobserver reliability (assessed by intraclass correlation coefficient (ICC)) was 0.94 (95% CI 0.89 to 0.98) for VDI and 0.78 (95% CI 0.63 to 0.93) for CDA. Intraobserver reliability was 0.92 (95% CI 0.83 to 1.00) for VDI and 0.87 (95% CI 0.75 to 1.00) for CDA. A total of 13 items were not used in the VDI compared to 23 in the CDA. Observers agreed that the CDA covered the full spectrum of damage attributable to vasculitis but was more time consuming and thus possibly less feasible for clinical and research purposes. Conclusions The VDI and CDA capture reliable data on damage among patients with vasculitis. The CDA captures more detail but is more complex and less practical than the VDI. Further evolution of damage assessment in vasculitis is likely to include key elements from both instruments.
引用
收藏
页码:80 / 85
页数:6
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