The First Synthesis of 3-Hydroxy-2-(polyfluoroalkyl)chromones and Their Ammonium Salts. 3-Hydroxychromone in the Mannich Reaction

被引：3

作者：

Irgashev, Roman A. ^{[1
]}

Sosnovskikh, Vyacheslav Ya ^{[1
]}

Sokovnina, Anna A. ^{[1
]}

Roeschenthaler, Gerd-Volker ^{[2
]}

机构：

[1] Ural State Univ, Dept Chem, Ekaterinburg 620083, Russia

[2] Univ Bremen, Inst Inorgan & Phys Chem, D-28334 Bremen, Germany

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2010年 / 47卷 / 04期

关键词：

2-POLYFLUOROALKYLCHROMONES; DERIVATIVES; ACID; HYDROXYLAMINE; AMINES; ROUTE;

D O I：

10.1002/jhet.386

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Hydroxy-2-(polyfluoroalkyl)chromones were obtained in good yields via the nitrozation reaction of 2-(polyfluoroalkyl)chroman-4-ones with isopropyl nitrite in the presence of hydrochloric acid. Treatment of 3-acetoxy-2-(trifluoromethyl)chromone with primary amines and hydrazine gave the corresponding ammonium salts. Reaction of 3-hydroxychromone, prepared by this method, with formaldehyde and alpha-aminoacids has been studied.

引用

页码：944 / 948

页数：5

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