Allyl as a protective group for the synthesis of modified oligonucleotides

被引：0
|
作者：
Zhou, Y [1 ]
Zhang, LR [1 ]
Zhang, LH [1 ]
机构：
[1] Peking Univ, Natl Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
来源：
ACTA CHIMICA SINICA | 2001年 / 59卷 / 10期
关键词：
allyl; palladium chloride; trithymidinyl dicarbonate; dithymidinyl sulfite;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The possibility of allyl as protective group of the hydroxyls in nucleosides for the synthesis of oligonucleotides was studied. Allyl group could be removed by PdCl2 under mild condition, it could be used for the synthesis of alkaline sensitive oligonucleotides. Trithymidinyl dicarbonate and dithymidinyl sulfite were synthesized in this report.
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页码：1691 / 1696
页数：6
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