Lehualides A-D, metabolites from a Hawaiian sponge of the genus Plakortis

被引：24
|
作者：
Sata, N
Abinsay, H
Yoshida, WY
Horgen, FD
Sitachitta, N [1 ]
Kelly, M
Scheuer, PJ
机构：
[1] Univ Hawaii Manoa, Dept Chem, Honolulu, HI 96822 USA
[2] Hawaii Pacific Univ, Coll Nat Sci, Kaneohe, HI 96744 USA
[3] NIWA, Auckland, New Zealand
来源：
JOURNAL OF NATURAL PRODUCTS | 2005年 / 68卷 / 09期
关键词：
D O I：
10.1021/np0500528
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A collection of an undescribed marine sponge of the genus Plakortis yielded four new "polyketide-derived" metabolites, lehualides A-D (1 -4). The structures of compounds 1 -4 were elucidated by interpretation Of spectral data. Compound 2 demonstrated cytotoxicity against an ovarian cancer cell line, while compound 4 was active against both ovarian cancer and leukemia cell lines.
引用
收藏
页码：1400 / 1403
页数：4
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